CVPR Week 4: Introduction to lipids Flashcards
Objectives
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/304/270/a_image_thumb.jpg?1554499027)
Epidemiology
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/304/420/a_image_thumb.jpg?1554499368)
Leading cause of death worldwide
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/304/615/a_image_thumb.jpg?1554499390)
Approaches to CVD prevention
4 listed
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/304/658/a_image_thumb.jpg?1554499412)
Lipoprotein management
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/304/678/a_image_thumb.jpg?1554499434)
CVD Risk
- Abnormal lipid metabolism
- ↑ LDL
- ↑ ApoB
- ↓ HDL
- ↑ Triglycerides
- Age, gender, race, FHx
- Inflammation, hypercoagualation
- HTN
- Smoking, physical inactivity
- Unhealthy eating
- Insulin resitance
- Obesity/overweight
Heart deaths during the last century
- in 1900 CVD very low
- decrease in mid-80s because the first statin was released in 1984 and HTN drugs
*
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/304/816/a_image_thumb.jpg?1554499660)
Features of a ruptured atherosclerotic plaque
eccentric
lipid-rich
prior luminal obstruction
visible rupture and thrombus
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/304/989/a_image_thumb.jpg?1554499830)
Identify
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/305/162/a_image_thumb.jpg?1554500090)
What are these?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/305/190/q_image_thumb.png?1554500174)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/305/190/a_image_thumb.jpg?1554500128)
What is this?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/305/250/q_image_thumb.png?1554500231)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/305/250/a_image_thumb.jpg?1554500231)
What do statins inhibit?
HMG-CoA Reductase
What do biphosphonates inhibit?
Farnesyl-PP synthase
Synthesis of cholesterol biochemistry
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/305/358/a_image_thumb.jpg?1554500334)
Ubiquinone AKA
Co-enzyme Q10
Muscle aches and pains from statin therapy
(Co-Q10) Ubiquinone supplement to decrease myalgias on statins (Co-Q10)
The process of fat digestion
8 steps listed
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/305/466/a_image_thumb.jpg?1554500455)
APO-lipoprotein B48
on chylomicron
Apoprotein C-II
increases efficiency of lipoprotein lipase on the intestinal wall
Lipoprotein lipase
breaks down triglycerides into Free-fatty acids
feeds muscle tissue and adipocytes and cells that can use FFAs
Identify
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/305/664/q_image_thumb.png?1554500827)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/305/664/a_image_thumb.jpg?1554500681)
Lipoprotein subclasses
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/305/710/a_image_thumb.jpg?1554501042)
Lpa is. . .
thrombogenic
Apo B can cause
CVD
ApoAI is
good cholesterol kind of
Lipoprotein metabolism
Fats into intestine LPL lipoprotein lipase breaks down into FAs and make chylomicron remnant to the liver and forms VLDL
CII improves LPL, CIII is antagonistic to CII
VLDL with LPL forms IDL
IDL with Hepatic lipase forms LDL
LDL donates cholesterol to the liver but sometimes it gets into the interluminalmedial space and gets oxidized
oxidized LDL gets phagocytosed by macrophages
ABCA1 (ATP binding Cassette A1) on macrophage allows free cholesterol to get into a Free nascent HDL particle that has APO-AI and some has APO-AII
HDL has a scavenger receptor B1 to donate cholesterol to the liver or other tissues and take excess cholesterol back to the liver and the liver can make bile and can be excreted or recycled
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/306/227/a_image_thumb.jpg?1554501141)
Size of Lipoproteins
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/306/840/a_image_thumb.jpg?1554501873)
Types of hypercholesterolemia
6 listed
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/306/869/a_image_thumb.jpg?1554501906)
Fill in the table
Type I
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/306/875/q_image_thumb.png?1554502147)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/306/875/a_image_thumb.jpg?1554502157)
Fill in the table
Type IIA
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/307/036/q_image_thumb.png?1554502196)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/307/036/a_image_thumb.jpg?1554502189)
Fill in the table
Type IIB
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/307/132/q_image_thumb.png?1554502226)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/307/132/a_image_thumb.jpg?1554502228)
Features of Type I Hypercholesterolemia
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/307/554/a_image_thumb.png?1554502664)
Features of Type IIA Hypercholesterolemia
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/307/568/a_image_thumb.png?1554502682)
Features of Type IIB Hypercholesterolemia
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/307/579/a_image_thumb.png?1554502698)
Features of Type III Hypercholesterolemia
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/307/616/a_image_thumb.png?1554502717)
Features of Type IV Hypercholesterolemia
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/307/624/a_image_thumb.png?1554502729)
Features of Type V Hypercholesterolemia
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/307/656/a_image_thumb.png?1554502757)
Cause of Type I Hypercholesterolemia
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/307/673/a_image_thumb.png?1554502779)
Cause of Type IIA Hypercholesterolemia
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/307/686/a_image_thumb.png?1554502790)
Cause of Type IIB Hypercholesterolemia
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/307/690/a_image_thumb.png?1554502810)
Cause of Type III Hypercholesterolemia
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/307/770/a_image_thumb.png?1554502829)
Cause of Type IV Hypercholesterolemia
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/307/772/a_image_thumb.png?1554502845)
Cause of Type V Hypercholesterolemia
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/307/775/a_image_thumb.png?1554502865)
Other features of Type I Hypercholesterolemia
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/307/785/a_image_thumb.png?1554502897)
Other features of Type IIA Hypercholesterolemia
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/307/800/a_image_thumb.png?1554502907)
Other features of Type IIB Hypercholesterolemia
![](https://s3.amazonaws.com/brainscape-prod/system/cm/273/307/806/a_image_thumb.png?1554502928)