CVPR Week 3: Autonomic Physiology of the Cardiovascular System Flashcards
Objectives

Peripheral nervous system divisions
2 listed
- autonomic nervous system
- somatic nervous system
Skeletal muscle is innervated by?
Efferent motor & afferent sensory neurons of the somatic nervous division
Voluntary nervous system AKA
Somatic nervous system
The autonomic nervous system innervates?
Organs and tissue that typically do not require conscious control
Involuntary nervous system AKA
Autonomic nervous system
Autonomic nervous system divisions
3 listed
- Sympathetic division
- Parasympathetic division
- Enteric Division
Most organs innervated by the ANS are innervated by this division?
By both the sympathetic and parasympathetic divisions of the ANS
The actions of the sympathetic and parasympathetic divisions are typically?
Antagonistic
An increase in sympathetic stimulation in the SA node will produce?
an increase in heart rate
An increase in parasympathetic stimulation in the SA node will produce?
a reduction in heart rate
How is homeostasis achieved by the ANS?
It is a balance of activity between the sympathetic and parasympathetic divisions of the ANS that helps maintain a stable environment in the face of changing external conditions
Tissues innervated only by one division of the ANS
Systemic vasculature is primarily innervated by the sympathetic division of the ANS
What system is primarily responsible for the regulation of heart rate, contractility and vascular tone?
The ANS
Properties of the Autonomic Nervous System

Sympathetic division organization

Parasympathetic division organization

Neurotransmitter release in ANS neurons

NE AKA
Norepinephrine
Sympathetic Nervous system neurotransmitters
Released at most postganglionic sympathetic nerve endings exceptions include the release of ACh at sweat glands and the release of dopamine at some renal arteries
Nerve fibers that release NE are referred to as?
Adrenergic fibers
A modified sympathetic ganglion
Adrenal medulla
Adrenal medulla properties
- is a modified sympathetic ganglion and is innervated by sympathetic preganglionic fibers
- These fibers synapse on chromaffin cells, which release epinephrine (adrenaline) and a smaller fraction of NE (noradrenaline) into the blood
- Therefore epinephrine and NE act as endocrine factors
Epinephrine and NE are known as?
Catecholamines
Some NE is actively transported back into the postganglionic neuron where it is?
Degraded by monoamine oxidase (MAO) in the mitochondria
ACh is released by
- ALL preganglionic autonomic fibers
- All postganglionic parasympathetic fibers
Nerve fibers that release ACh are called?
Cholinergic fibers
Once ACh has been degraded it is?
Choline actively transported back into the postganglionic varicosity and used to synthesize additional ACh
ACh is degraded by?
Acetylcholinesterase
ACh is degraded into?
Choline and acetate
Drugs to treat cocaine intoxication

CNS effects of cocaine and nicotine

CP effects of cocaine

Crack lung?
cocaine myocardial supply and demand effects
Other effects of cocaine

Clinical indicators of shock

Do not treat cocaine intoxication with?
β-blockers!!!!!
Adrenergic receptors

Mottling is suggestive of
shock
Question


Explain the RAS system

Renin synthesis and release

Question


Question explanation


Question: Part A


Question: Part B


Question: Part A


Question: Part B


Question: Part C


Question: Part D


Question: Part E


Question: Part A


Question: Part B


Question: Part C


Question: Part A


Question 6: Part B


Question 6: Part C


Responses to β receptor stimulation

Question 6: Part D


What are these?

