CVPR Week 5: Gas Transport I Flashcards
Objectives
Gas exchange procedure
5 listed
- Atmosphere to alveoli
- Alveoli to pulmonary capillary
- Pulmonary capillaries to tissues
- tissue extraction
- CO2 transfer
Explain the process of gas exchange
- Atmosphere to alveoli
- Alveoli to pulmonary capillary
- Pulmonary capillaries to tissues
- tissue extraction
- CO2 transfer
The PO2 depends on?
Barometric pressure PB
Daltons law of partial pressures
Total pressure = summation of partial pressures
Atmospheric PO2 vs inspired PO2
Tracheobronchial tree structural description
Tracheobronchial tree zones
Cross-sectional area in different portions of the lung
Surface area of the respiratory bronchiols
~140 m2
speed of flow in the respiratory bronchioles
V = Q / A
From the atmosphere to alveoli
What are these?
Alveoli
Factors affecting diffusion in the alveoli
3 listed
Fick’s Law of diffusion
How is O2 carried in the blood?
2 listed
Dissolved and bound to Hb
Typically, how much blood is transported in either state?
Alveoli to pulmonary capillaries
Movement of O2 between alveolar gas and pulmonary capillary blood is determined by?
Fick’s law of diffusion
Diffusion is impaired by?
thickened barrier (such as in pulmonary fibrosis) or a reduced driving pressure (↓ alveolar PO2 at altitude or COPD)
How is diffusion impaired by pulmonary fibrosis?
Thickened barrier
how does a reduced PO2 impair diffusion
reduced driving pressure
How does COPD impair diffusion?
Reduced driving pressure
O2 content is defined by?
the total amount of O2 carried in the blood (Dissolved + HbO2)
The majority of O2 carried in the blood is?
bound to Hb (HbO2)
