CVPR Week 5: Gas Transport II Flashcards
Pulmonary capillaries to tissues
oxygenated blood travels to the left heart where it is pumped to the periphery
Total O2 delivery =
Total O2 delivery = CO x O2 content
Exercise effect on O2 delivery
With exercise, O2 delivery is increased by increasing CO
Tissue extraction
HbO2 dissociation curve shape
Factors that affect O2 delivery to tissues
Factors that ↑ O2 delivery to tissues
Factors that ↓ O2 delivery to tissues
Effects of Hematocrit and Carbon monoxide on O2 delivery
O2 uptake at the lung
The curvilinear shape of the HbO2 dissociation curve facilitates O2 uptake at the lung and O2 unloading at the tissue
The rightward shift of the HbO2 dissociation curve and under what conditions
(Increased P50) increases tissue O2 delivery
when
- ↑PCO2
- ↓pH
- ↑ Temperature
- ↑ 2,3-BPG
The leftward shift of the HbO2 dissociation curve and under what conditions
(Decreased P50) impedes tissue O2 delivery
when
↓ Temperature
↓ PCO2
↓2,3-DPG
↑pH
How is O2 content determined in the blood?
Blood Hb content is critical in determining O2 content
(Anemia/Polycythemia)
CO effects on O2 delivery
- CO not only reduces O2 content but also decreases P50
- Both of which impair O2 delivery
How is CO2 transported
- Bicarbonate
- Carbaminohemoglobin
- Dissolved
How much CO2 transported as bicarbonate ion
HCO3 70%
How is CO2 transported as Carbaminohemoglobin?
HbCO2 20%
How is CO2 transported dissolved?
~ 10%
CO2 transport
Interaction of CO2 and O2 transport in the tissues
Bohr effect
Interaction of CO2 and O2 transport in the alveoli
Effects of O2 on the CO2 dissociation curve
Haldane effect: Mechanisms
Summary of CO2 transport
