CVPR Week 2: Pharmacology of Antiarrhythmic agents Flashcards
Objectives
Classes of antiarrhythmic drugs
Class I antiarrhythmics groups
Na+ channel block
Class I antiarrhythmics: Group IA
Effect of Class I antiarrhythmics: Group IA
Class I antiarrhythmics: Group IA effects on AP
Procainamide side effects
and lupus-like syndrome
Torsade Du Pointe
Torsade Du Pointe is more likely in?
Procainamide side effects
- torsade du pointes
- and lupus like syndrome
Procainamide drug interactions
Class I antiarrhythmics: Group IA major action
Prolong AP duration
Dissociate with intermediate kinetics (3 sec)
Class I antiarrhythmics: Group IB major action
slightly shorten AP duration
Dissociation with rapid kinetics (<1sec)
Class I antiarrhythmics: Group IC major action
- Minimal effect on AP duration
- Dissociate with rapid kinetics
Class I antiarrhythmics: Group IB major action & agents
Lidocaine kinetics
Class I antiarrhythmics: Group IB effect on AP
Associate lidocaine with?
Ventricular compartment
Lidocaine caveat
Class I antiarrhythmics: Group IB adverse effects
Class I antiarrhythmics: Group IB drug interactions
Class I antiarrhythmics: Group IC effects on AP
Class I antiarrhythmics: Group IC agents
Class I antiarrhythmics: Group IC uses
Class I antiarrhythmics: Group IC adverse effects
Class I antiarrhythmics: Group IC drug interactions
Class II antiarrhythmics: Major action
β-receptor blockade
Review of SA node action potential
β-receptor activation increases?