CVPR Week 2: Pharmacology of Antiarrhythmic agents Flashcards

1
Q

Objectives

A
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2
Q

Classes of antiarrhythmic drugs

A
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3
Q

Class I antiarrhythmics groups

A

Na+ channel block

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4
Q

Class I antiarrhythmics: Group IA

A
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5
Q

Effect of Class I antiarrhythmics: Group IA

A
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6
Q

Class I antiarrhythmics: Group IA effects on AP

A
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7
Q

Procainamide side effects

A

and lupus-like syndrome

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8
Q

Torsade Du Pointe

A
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9
Q

Torsade Du Pointe is more likely in?

A
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10
Q

Procainamide side effects

A
  • torsade du pointes
  • and lupus like syndrome
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11
Q

Procainamide drug interactions

A
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12
Q

Class I antiarrhythmics: Group IA major action

A

Prolong AP duration

Dissociate with intermediate kinetics (3 sec)

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13
Q

Class I antiarrhythmics: Group IB major action

A

slightly shorten AP duration

Dissociation with rapid kinetics (<1sec)

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14
Q

Class I antiarrhythmics: Group IC major action

A
  • Minimal effect on AP duration
  • Dissociate with rapid kinetics
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15
Q

Class I antiarrhythmics: Group IB major action & agents

A
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16
Q

Lidocaine kinetics

A
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17
Q

Class I antiarrhythmics: Group IB effect on AP

A
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18
Q

Associate lidocaine with?

A

Ventricular compartment

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19
Q

Lidocaine caveat

A
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20
Q

Class I antiarrhythmics: Group IB adverse effects

A
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21
Q

Class I antiarrhythmics: Group IB drug interactions

A
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22
Q

Class I antiarrhythmics: Group IC effects on AP

A
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23
Q

Class I antiarrhythmics: Group IC agents

A
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24
Q

Class I antiarrhythmics: Group IC uses

A
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25
Q

Class I antiarrhythmics: Group IC adverse effects

A
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26
Q

Class I antiarrhythmics: Group IC drug interactions

A
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27
Q

Class II antiarrhythmics: Major action

A

β-receptor blockade

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28
Q

Review of SA node action potential

A
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29
Q

β-receptor activation increases?

A
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30
Q

β-receptor activation activates?

A
31
Q

Class II antiarrhythmics: Mechanism of antiarrhythmic action

A
32
Q

Class II antiarrhythmics: Effects on AP

A
33
Q

β-receptor blocker classification

A
34
Q

β-receptor blocker Mnemonics

A
35
Q

β-receptor blocker antiarrhythmic use

A
36
Q

β-receptor arrhythmic common adverse effects

A
37
Q

β-receptor blocker other adverse effects

A
38
Q

Class II antiarrhythmics: drug interactions

A
39
Q

antidote for β-receptor blocker overdose

A

Glucagon (isoproterenol)

40
Q

Class IV antiarrhythmics: major actions

A

Ca2+ channel block

41
Q

Class IV antiarrhythmics: SA Nodal potential

A
42
Q

Class IV antiarrhythmics: mechanism of antiarrhythmic action

A
43
Q

Class IV antiarrhythmics: effect on AP

A
44
Q

Class IV antiarrhythmics: types of Ca2+ channel blockers

A
45
Q

Class IV antiarrhythmics: uses of Ca2+ channel blockers

A
46
Q

Class IV antiarrhythmics: cardiac adverse effects

A
47
Q

Class IV antiarrhythmics: drug interactions

A
48
Q

Class III antiarrhythmics: Major action

A
49
Q

Class III antiarrhythmics: Agents

A
50
Q

Class III antiarrhythmics: Amiodarone Mechanism of action

A
51
Q

Class III antiarrhythmics: Amiodarone effect on AP

A
52
Q

Class III antiarrhythmics: Amiodarone clinical uses

A
53
Q

Class III antiarrhythmics: Amiodarone adverse effects 1

A
54
Q

Class III antiarrhythmics: Amiodarone adverse effects 2

A
55
Q

What causes this?

A

Class III antiarrhythmics: Amiodarone adverse effects

56
Q

Class III antiarrhythmics: Drug interactions

A
57
Q

antiarrhythmics Summary table

A
58
Q

Miscellaneous Antiarrhythmics agents

A
59
Q

Adenosine MOA K channels

A
60
Q

Adenosine MOA Ca channels

A
61
Q

Adenosine cardiac areas of effect

A
62
Q

Adenosine effects

A
63
Q

Adenosine effects on AP

A
64
Q

Adenosine uses

A
65
Q

Adenosine adverse effects

A
66
Q

Adenosine drug interactions

A
67
Q

Digoxin class

A

Miscellaneous antiarrhythmics

68
Q

Digoxin MOA 1

A
69
Q

Digoxin MOA 2

A
70
Q

Digoxin MOA caveat

A
71
Q

Digoxin toxicity

A
72
Q

Digoxin drug interactions

A
73
Q

Magnesium and Potassium class

A
74
Q

Miscellaneous Antiarrhythmics summary

A