CVPR Week 2: Pharmacology of Antiarrhythmic agents Flashcards
Objectives
Classes of antiarrhythmic drugs
Class I antiarrhythmics groups
Na+ channel block
Class I antiarrhythmics: Group IA
Effect of Class I antiarrhythmics: Group IA
Class I antiarrhythmics: Group IA effects on AP
Procainamide side effects
and lupus-like syndrome
Torsade Du Pointe
Torsade Du Pointe is more likely in?
Procainamide side effects
- torsade du pointes
- and lupus like syndrome
Procainamide drug interactions
Class I antiarrhythmics: Group IA major action
Prolong AP duration
Dissociate with intermediate kinetics (3 sec)
Class I antiarrhythmics: Group IB major action
slightly shorten AP duration
Dissociation with rapid kinetics (<1sec)
Class I antiarrhythmics: Group IC major action
- Minimal effect on AP duration
- Dissociate with rapid kinetics
Class I antiarrhythmics: Group IB major action & agents
Lidocaine kinetics
Class I antiarrhythmics: Group IB effect on AP
Associate lidocaine with?
Ventricular compartment
Lidocaine caveat
Class I antiarrhythmics: Group IB adverse effects
Class I antiarrhythmics: Group IB drug interactions
Class I antiarrhythmics: Group IC effects on AP
Class I antiarrhythmics: Group IC agents
Class I antiarrhythmics: Group IC uses
Class I antiarrhythmics: Group IC adverse effects
Class I antiarrhythmics: Group IC drug interactions
Class II antiarrhythmics: Major action
β-receptor blockade
Review of SA node action potential
β-receptor activation increases?
β-receptor activation activates?
Class II antiarrhythmics: Mechanism of antiarrhythmic action
Class II antiarrhythmics: Effects on AP
β-receptor blocker classification
β-receptor blocker Mnemonics
β-receptor blocker antiarrhythmic use
β-receptor arrhythmic common adverse effects
β-receptor blocker other adverse effects
Class II antiarrhythmics: drug interactions
antidote for β-receptor blocker overdose
Glucagon (isoproterenol)
Class IV antiarrhythmics: major actions
Ca2+ channel block
Class IV antiarrhythmics: SA Nodal potential
Class IV antiarrhythmics: mechanism of antiarrhythmic action
Class IV antiarrhythmics: effect on AP
Class IV antiarrhythmics: types of Ca2+ channel blockers
Class IV antiarrhythmics: uses of Ca2+ channel blockers
Class IV antiarrhythmics: cardiac adverse effects
Class IV antiarrhythmics: drug interactions
Class III antiarrhythmics: Major action
Class III antiarrhythmics: Agents
Class III antiarrhythmics: Amiodarone Mechanism of action
Class III antiarrhythmics: Amiodarone effect on AP
Class III antiarrhythmics: Amiodarone clinical uses
Class III antiarrhythmics: Amiodarone adverse effects 1
Class III antiarrhythmics: Amiodarone adverse effects 2
What causes this?
Class III antiarrhythmics: Amiodarone adverse effects
Class III antiarrhythmics: Drug interactions
antiarrhythmics Summary table
Miscellaneous Antiarrhythmics agents
Adenosine MOA K channels
Adenosine MOA Ca channels
Adenosine cardiac areas of effect
Adenosine effects
Adenosine effects on AP
Adenosine uses
Adenosine adverse effects
Adenosine drug interactions
Digoxin class
Miscellaneous antiarrhythmics
Digoxin MOA 1
Digoxin MOA 2
Digoxin MOA caveat
Digoxin toxicity
Digoxin drug interactions
Magnesium and Potassium class
Miscellaneous Antiarrhythmics summary
