Chapter 66 - Bladder Flashcards
What is the bladder’s capacity in a 500-kg horse, and how does its position change when empty or full?
The bladder can hold** 4 L or more of urin**e in a 500-kg horse. When empty, it may lie entirely in the pelvic canal, and when full, it drops over the pelvic brim to extend to the level of the umbilicus.
What are the round ligaments of the bladder, and what is their origin?
The round ligaments of the bladder are the cranial free edges of the lateral ligaments, remnants of the umbilical arteries.
How is the bladder covered anatomically, both cranially and in the remainder of the retroperitoneal space?
Cranially at the apex, the bladder is covered with peritoneum, and in the remainder of the retroperitoneal space, it is covered with adventitial tissue.
What are the two muscle layers in the bladder wall, and how are they arranged anatomically?
Bladder wall contains an** outer layer of longitudinal** to obliquely arranged muscle fibers
**inner layer of transversely **or **circularly arranged **muscle fibers.
They are partly interwoven but become external to each other at the dorsal aspect.
Why is the dorsal wall of the bladder considered inherently weak, and what is the potential consequence of excessive bladder distention?
The** dorsal wall** is considered** weak** due to the anatomical arrangement of muscle fibers. Excessive bladder distention may lead to rupture, particularly at the dorsal wall.
What muscles form the urethral sphincter, and how are they arranged around the pelvic urethra?
The urethral sphincter is formed by an outer longitudinal and an inner circular layer of smooth muscle surrounding the pelvic urethra.
What is the lining of the bladder, and what allows the bladder to stretch considerably during filling?
the bladder is lined with transitional epithelium overlying a thick submucosa that allows considerable stretching.
How is sympathetic innervation provided to the bladder, and what receptors do the fibers supply in the bladder and proximal urethra?
Sympathetic innervation is provided via the hypogastric nerve, with fibers supplying the** bladder** (β2-adrenergic receptors) and proximal urethra (primarily α1- and some α2-adrenergic receptors).
What is the origin of parasympathetic innervation for the bladder, and how is somatic innervation primarily directed to the lower urinary tract?
Parasympathetic innervation originates in the sacral segments of the spinal cord, forming the pelvic nerve.
Somatic innervation is primarily directed to the lower urinary tract via a branch of the pudendal nerve.
What is the detrusor muscle, and how is it innervated in the bladder wall?
The detrusor muscle is the smooth muscle of the bladder wall. It is innervated by the parasympathetic pelvic nerve and β2-adrenergic postganglionic fibers.
Describe the filling/storage phase of the bladder, and what is the role of sympathetic nerve activity during this phase?
During filling/storage, there is an increase in tone of the urethral sphincter muscles. Sympathetic nerve activity is dominant, leading to relaxation of the detrusor muscle
What receptors mediate the relaxation of the detrusor muscle during the filling/storage phase?
Relaxation of the detrusor muscle during filling/storage is mediated by α-receptor–mediated inhibition of pelvic nerve afferents and stimulation of sympathetic β2 receptors in the smooth muscle of the bladder.
How is the detrusor muscle reflexively relaxed during bladder filling, and what triggers detrusor contraction during the elimination phase?
the detrusor muscle reflexively **relaxes during bladder filling due to sensory input from bladder stretch and pressure receptors**. Detrusor contraction is triggered by signals for voluntary micturition during the elimination phase.
What is the role of brainstem upper motor neurons in micturition, and what triggers the end of micturition?
Brainstem upper motor neurons transmit signals to trigger detrusor contraction during micturition. Micturition ends when detrusor stretch receptors cease firing, and pelvic nerve efferent activity stops.
How is sympathetic nerve and pudendal nerve activity involved in the post-micturition storage/filling phase?
Sympathetic nerve and pudendal nerve activity resumes for the next storage/filling phase after micturition.
What triggers the initiation of voluntary micturition signals, and what muscles are concurrently inhibited during this phase?
Voluntary micturition signals are initiated in the cerebrum, leading to the inhibition of pudendal nerve and hypogastric α- and β2-sympathetic activity, allowing relaxation of the urethral sphincter and facilitating detrusor muscle contraction.
How does sympathetic innervation contribute to the relaxation of the detrusor muscle during the filling/storage phase?
Sympathetic innervation leads to the relaxation of the detrusor muscle during the filling/storage phase by inhibiting pelvic nerve afferents and stimulating sympathetic β2 receptors in the smooth muscle of the bladder.
What are some disorders of the bladder that may necessitate surgery in horses?
Foals:
- uroperitoneum,
- patent urachus,
In adult horses,
- cystolithiasis/urolithiasis
- prolapse or eversion of bladder
- neoplasia
What is the most common surgical disorder of the bladder in adult horses?
Cystolithiasis
What can cause uroperitoneum in foals, and what is the prevalence of uroperitoneum after bladder rupture during parturition in colts?
Uroperitoneum in foals can result from bladder rupture during parturition in colts. The prevalence ranges from 0.5% to 2.5%.
What is the commonly accepted explanation for bladder rupture in colts during parturition?
high intravesicular pressure during passage through the pelvic canal and occlusion of the urethra.
what is the typical appearance of bladder tears in foals?
Bladder tears are typically** 2 to 5 cm in length** on the dorsal surface, with hemorrhagic and edematous margins.
What are the potential causes of bladder distention in stillborn and neonatal foals, and how can bladder distention be confused with uroabdomen?
Potential causes of bladder distention in stillborn and neonatal foals include excessively long umbilical cords and anomalies in bladder-urachus fusion. Bladder distention can be confused with uroabdomen, as seen in cases of enlarged, flaccid bladders.
what is the treatment of megavesica in foals
Surgical removal of a large portion of the bladder is the treatment for megavesica with uroabdomen in foals.