Chapter 61 - Penis and prepuce II surgery Flashcards
What is a common cause of genital squamous cell carcinoma in horses?
Lack of pigmentation, particularly in older geldings or stallions.
What is hypospadias?
A congenital defect where the urethral meatus is abnormally located.
What conditions may accompany hypospadias in horses?
Chordee, incomplete prepuce, and meatal stenosis.
How is hypospadias in horses usually managed if it causes discomfort?
By amputation of the malformed penile portion.
What type of intersex condition is common in horses?
Male pseudohermaphroditism.
How can a pseudohermaphrodite horse’s appearance be altered?
By amputation or repositioning of the genitalia.
What is the most frequent neoplasm of the horse’s external genitalia?
Squamous cell carcinoma.
What factors might predispose certain horse breeds to genital carcinoma?
Nonpigmented genitalia and chronic irritation from smegma.
What virus is associated with genital squamous cell carcinoma in horses?
Equus caballus papillomavirus type 2 (EcPVpv2).
What are common symptoms of advanced squamous cell carcinoma in horses?
Ulceration, necrosis, and possibly a malodorous discharge.
What type of laser is used to excise squamous cell carcinoma on the external genitalia?
Carbon dioxide laser.
What is a potential benefit of using a laser for excision over traditional methods?
It reduces postoperative swelling and has a thermal killing effect on marginal tumor cells.
What surgical procedures may be necessary for horses with extensive neoplastic lesions on the genitalia?
Preputial reefing or partial phallectomy.
What is the last-resort surgical procedure for extreme cases of neoplastic lesions?
Prescrotal urethrostomy with en bloc resection.
What material is typically used in cryotherapy for squamous cell carcinoma?
Liquid nitrogen or CO₂.
What is the ideal freezing and thawing cycle in cryotherapy for the best results?
A double, fast freeze–slow thaw cycle.
Which topical drug is used for small genital lesions in horses?
5% 5-fluorouracil.
How often is 5-fluorouracil applied to lesions?
Every 14 days.
What intratumoral chemotherapy drug is used in combination with surgery for squamous cell carcinoma?
Cisplatin.
Why is debulking a tumor before chemotherapy beneficial?
It lowers the tumor burden, making remaining cells more responsive to cisplatin.
What side effect is avoided by administering cisplatin directly into the tumor bed during surgery?
There is no detrimental effect on wound healing.
What treatment technique uses electrical pulses to improve drug delivery to neoplastic cells?
Electrochemotherapy.
What effect does electroporation have on cisplatin efficacy?
It can increase cytotoxicity up to 70 times in vitro.
What percentage of blood flow reduction occurs in tumors post-electroporation, aiding drug retention?
60–70%.