Blood & Hematopoiesis Flashcards
neutrophils undergo ________ at sites of acute bacterial infections
demargination
what cell gives rise to macrophages?
monocytes
granulopoiesis (granulocyte development) characteristics
acquisition of cytoplasmic granules
endomitosis occurs in what cell lineage?
platelet
neutrophils
Pus is the thick, opaque, usually yellow-white fluid matter formed in response to invasion of the body by infective microorganisms
PUS=neutropil=bacterial infection
eosinophils
what blood cell progenitors is no longer capable of division?
orthochromatophilic erythroblasts
where do hematopoietic stem cells and blood cell production appear first during human development?
yolk sac
histamine produced by basophils
which of the following is true about neutrophils?
a. undergo demargination at sites of acute bacterial infections
b. give rise to plasma cells
c. release thromboplastin during the clotting process
d. give rise to macrophages
e. contain major basic protein
a. undergo demargination at sites of acute bacterial infections
what cell gives rise to macrophages?
a. proerythroblasts
b. megakaryocytes
c. reticulocytes
d. monocytes
e. metamyelocyte
d. monocytes
which of the following is a characteristic of granulopoiesis?
a. eventual pyknotic degradation of the nucleus
b. stimulated by thrombopoietin
c. will eventually give rise to plasma cells
d. maintenance of round nucleus
e. acquisition of cytoplasmic granules
e. acquisition of cytoplasmic granules
endomitosis occurs in what cell lineage?
a. lymphocyte
b.platelet
c. monocyte
d. granulocyte
e. erythrocyte
b. platelet
a. basophils
b. neutrophils
c. eosinophils
d. erythrocytes
e. lymphocytes
b. neutrophils
pus = bacterial infections = neutrophils (1st responders)
a. basophils
b. lymphocytes
c. neutrophils
d. eosinophils
e. monocytes
d. eosinophils
parasite = eosinophils
which of the following blood cell progenitors is NO longer capable of division?
a. basophilic erythroblast
b. myeloblast
c. orthochromatophilic erythroblast
d. polychromatophilic erythroblast
e. myelocyte
c. orthochromatophilic erythroblast
differentiated = non mitotic
where do hematopoietic stem cells and blood cell production appear first during human development?
a. thymus
b. spleen
c. liver
d. bursa of fabrics
e. yolk sac
e. yolk sac
a. NADPH oxidase produces by neutrophils
b. major basic protein produced by eosinophils
c. IgG antibody produced by plasma cells
d. histamine produced by basophils
e. thromboplastin produced by platelets
d. histamine produced by basophils
hematopoiesis: there is continual ____ _____ and ____ ___
there is continual central production and peripheral destruction
T/F: Marrow is considered peripheral and the rest of the body is central
false
marrow=central
rest of body=peripheral
what are the two sources of adult bone marrow hematopoietic stem cells (found in the embryo)?
yolk sac
dorsal aorta
label
label arrows/sections
green arrow: differentiation
red arrow: potential
what do myeloid stem cells give rise to?
Myeloid stem cells:
blood cells/erythroid CFUs
megakaryocyte
eosinophils
basophils
neutrophils
monocyte
monocyte
Lymphoid:
B cells
Tcells
what do lymphoid stem cells give rise to?
Lymphoid stem cells:
B cells (bone marrow)
T cells (thymus)
Myeloid stem cells:
blood cells/erythroid CFUs
megakaryocyte
eosinophils
basophils
neutrophils
monocyte
CSF (what does it stand for) contribute to what?
CSF: colony-stimulating factors
CSF and cytokines stimulate the proliferation of progenitor and precursor cells
promote cell differentiation/maturation
if bone marrow is damaged, ______ ______ can occur. Typically in the spleen and liver
extramedullary hematopoiesis
erythrocyte developmental series cells (5)
proerythroblasts
basophilic erythroblasts
polychromatophilic erythroblasts
orthochromatophilic erythroblasts
reticulocytes
RBC
name the mitotic cells and non-mitotic cells of erythrocyte development
mitotic:
proerythroblasts
basophilic erythroblasts
polychromatophilic erythroblasts
non-mitotic:
orthochromatophilic erythroblasts
reticulocytes
RBC
blood cell homeostasis: production rates are regulated by ____ and respond to stresses (like infection)
cytokines
embryonic hematopoietic stem cells migrate to the developing ____
liver
fetal liver becomes the major source of hematopoietic stem cells
What stem cells do all blood cells arise from?
multipotential hematopoietic stem cells
growth factors of hematopoiesis
erythropoietin
thrombopoietin
cytokines
diverse set of protein hormones
involved in immune system activities and hematopoiesis
cords (hematopoietic marrow)
hematopoietic tissue between sinuses
sinusoids (hematopoietic marrow)
blood cells and platelets enter circulation via sinusoids
adventitial reticular cells
form meshwork to support cords of hematopoietic marrow
cells undergo developmental changes: what happens to the nucleus?
nucleoli disappear
chromatin gets clumpy
heterochromatin increases
euchromatin decreases
cells undergo developmental changes: what happens to the cytoplasm?
hemoglobin or granules increase
basophilic staining decreases
RNA decreases
erythrocyte developmental series:
name the cell
mitotic or non-mitotic?
proerythroblast
mitotic
erythrocyte developmental series:
name the cell
mitotic or non-mitotic?
basophilic erythroblast
mitotic
erythrocyte developmental series:
name the cell
mitotic or non-mitotic?
polychromatophilic erythroblast
mitotic
erythrocyte developmental series:
name the cell
mitotic or non-mitotic?
orthochromatophilic erythroblast
non- mitotic
erythrocyte developmental series:
name the cell
mitotic or non-mitotic?
reticulocyte
non-mitotic
erythrocyte developmental series:
name the cell
mitotic or non-mitotic?
RBC
non-mitotic
granulocyte developmental series:
list the cells
mitotic vs. non-mitotic
mitotic:
myeloblast
promyelocyte
myelocyte
non-mitotic:
metamyelocyte
band form
mature form (neutrophil)
list the cells in the granulocyte developmental series
list cells in granulocyte maturation
what cell produces blood platelets (in bone marrow)?
is regulated by thrombopoietin?
megakaryocyte
platelet formation is produced by what?
megakaryocyte