BIO - TERMS - CYTOKINE Flashcards
APRIL
A TNF family cytokine related to BAFF that binds the receptors TACI and BCMA on B cells to promote survival and regulate differentiation.
biologics therapy
Medical treatments comprising natural proteins such as antibodies and cytokines, and antisera or whole cells.
class I cytokine receptors
A group of receptors for the hematopoietin superfamily of cytokines. These include receptors using the common γ chain for IL-2, IL-4, IL-7, IL-15, and IL-21, and a common β chain for GM-CSF, IL-3, and IL-5.
class II cytokine receptors
A group of heterodimeric receptors for a family of cytokines that includes interferon (IFN)-α, IFN-β, IFN-γ, and IL-10.
common β chain
A transmembrane polypeptide (CD131) that is a common subunit for receptor of the cytokines IL-3, IL-5, and GM-CSF.
common γ chain (γc)
A transmembrane polypeptide chain (CD132) that is common to a subgroup of cytokine receptors.
cytokine storm
Overproduction of cytokines; can cause damage to the human body.
endogenous pyrogens
Cytokines that can induce a rise in body temperature.
gout
Disease caused by monosodium urate crystals deposited in the cartilaginous tissues of joints, causing inflammation. Urate crystals activate the NLRP3 inflammasome, which induces inflammatory cytokines.
homing receptors
Receptors on lymphocytes for chemokines, cytokines, and adhesion molecules specific to particular tissues, and which enable the lymphocyte to enter that tissue.
IFN-α, IFN-β
Antiviral cytokines produced by a wide variety of cells in response to infection by a virus, and which also help healthy cells resist viral infection. They act through the same receptor, which signals through a Janus-family tyrosine kinase. Also known as the type I interferons.
IFN-γ
A cytokine of the interferon structural family produced by effector CD4 TH1 cells, CD8 T cells, and NK cells. Its primary function is the activation of macrophages, and it acts through a different receptor from that of the type I interferons.
IL-1 family
One of four major families of cytokines, this family contains 11 cytokines that are structurally similar to IL-1α, and are largely proinflammatory in function.
IL-21
A cytokine produced by T cells (e.g.,TFH cells) that activates STAT3 and promotes survival and proliferation, particularly germinal center B cells.
inflammatory monocytes
An activated form of monocyte producing a variety of pro-inflammatory cytokines.