BIO - TERMS - BLOOD Flashcards
acute phase
In reference to HIV infection, the period that occurs soon after a person becomes infected. It is characterized by an influenza-like illness, abundant virus in the blood, and a decrease in the number of circulating CD4 T cells.
acute-phase response
A change in the proteins present in the blood that occurs during the early phases of an infection. It includes the production of acute-phase proteins, many of which are produced in the liver.
agammaglobulinemia
An absence of antibodies in the blood. See also X-linked agammaglobulinemia (XLA).
anastomosis
(ă-nas′tō-mō′sis; pl., anastomoses, -sēz) Union of two structures, such as blood vessels, to supply the same region.
angioplasty
(an′jē-ō-plas′tē) The reopening of a blood vessel through a variety of means.
angiotensinogen
An inactive or precursor liver protein that, when activated, may lead to a series of compounds that are involved in water and sodium regulation as well as blood pressure.
aortic body
Structure composed of neurons sensitive to changing levels of blood pH, CO2, and O2; located in the aortic arch. aperture (ap′er-chūr) Open gap or hole.
arteriovenous oxygen difference
(a-VO2 difference)— The oxygen difference between the arterial and mixed venous blood. This reflects the amount of oxygen used by the tissue.
artery
(ar′ter-ē) Blood vessel that transports blood away from the heart.
atherosclerosis
(ath′er-ō-sklerō′ sis) Disease in which an artery wall thickens, leaving a smaller lumen for blood flow.
atrium
(ā′trē-ŭm; pl., atria, ā′trē-ă) Chamber or cavity to which are connected other chambers or passageways; e.g., the heart has both a right atrium and a left atrium that are thin-walled, superior chambers that receive blood returning to the heart.
atypical hemolytic uremic syndrome
A condition characterized by damage to platelets and red blood cells and inflammation of the kidneys that is caused by uncontrolled complement activation in individuals with inherited deficiencies in complement regulatory proteins.
bacteremia
A condition in which there are bacteria in the blood.
cafestol
A molecule found in coffee that is thought to have strong anticancer properties but that may also elevate blood cholesterol levels.
capillary
(kap′i-lār-ē) The smallest blood vessel, its thin walls allow movement of substances between blood and interstitial fluid.
carotid body
Contains neurons sensitive to changing levels of blood pH, CO2, and O2; located at the bifurcation of the common carotid artery.
carotid sinus
(sı̄′nŭs) Baroreceptors sensitive to changes in blood pressure; located in the internal carotid arteries.
carpal
(kar′păl) Relating to the wrist. carrier Protein that binds a molecule to transport the molecule across the plasma membrane or within the blood; also, a person with one recessive mutant allele.
CD31
A cell-adhesion molecule found both on lymphocytes and at endothelial cell junctions. CD31–CD31 interactions are thought to enable leukocytes to leave blood vessels and enter tissues.
cerebrovascular accident (CVA)
Altered brain activity caused by reduced blood supply to the brain. It may result in permanent damage.
chloride shift
The movement of chloride ions from the plasma into red blood cells when carbon dioxide is transferred from tissues to the plasma, which allows blood pH to be maintained.
chronic allograft vasculopathy
Chronic damage that can lead to late failure of transplanted organs. Arteriosclerosis of graft blood vessels leads to hypoperfusion of the graft and its eventual fibrosis and atrophy.
coagulation
(kō-ag-yū-lā′-shŭn) Formation of a blood clot.
Contact-phase activation
The very first reactions in the intrinsic pathway of blood clotting.
coronary
(kōr′o-nār-ē) Denoting the blood vessels or other structures and activities related to the heart.
cross-matching
A test used in blood typing and histocompatibility typing to determine whether donor and recipient have antibodies against each other’s cells that might interfere with successful transfusion or grafting.
diastolic blood pressure
The lowest blood pressure exerted by the blood against the walls of the blood vessels when the heart is in relaxation.
diastolic pressure
(dı̄-ă-stol′ik) Blood pressure measured in an artery during diastole.
disseminated intravascular coagulation (DIC)
Blood clotting occurring simultaneously in small vessels throughout the body in response to disseminated TNF-α, which leads to the massive consumption of clotting proteins, so that the patient’s blood cannot clot appropriately. Seen in septic shock.
dysentery
A disease characterized by frequent, watery stools containing blood and mucus.
embolus
(em-bō′lŭs) Dislodged blood clot or air bubble traveling through the blood.
end-diastolic volume (EDV)
Volume of blood in the ventricle at the end of diastole (relaxation).
end-systolic volume (ESV)
Volume of blood in the ventricle at the end of systole (contraction).
endothelial activation
The changes that occur in the endothelial walls of small blood vessels as a result of inflammation, such as increased permeability and the increased production of cell-adhesion molecules and cytokines.
eosinophilia
An abnormally large number of eosinophils in the blood. eosinophils A type of white blood cell containing granules that stain with eosin. It is thought to be important chiefly in defense against parasitic infections, but is also medically important as an effector cell in allergic reactions.
ER tail-anchored proteins
Membrane proteins anchored in the endoplasmic reticulum (ER) membrane by a single transmembrane α helix contained at their C-terminus. erythrocyte Small hemoglobin-containing blood cell of vertebrates that transports oxygen to, and carbon dioxide from, tissues. Also called a red blood cell.
erection
(ē-rek′shŭn) Erectile tissues in the penis fill with blood and cause the penis to enlarge and become firm.
essential hypertension
High blood pressure in the absence of any known cause.
extravasation
The movement of cells or fluid from within blood vessels into the surrounding tissues.
familial hemophagocytic lymphohistiocytosis (FHL)
A family of progressive and potentially lethal inflammatory diseases caused by an inherited deficiency of one of several proteins involved in the formation or release of cytolytic granules. Large numbers of polyclonal CD8-positive T cells accumulate in lymphoid and other organs, and this is associated with activated macrophages that phagocytose blood cells, including erythrocytes and leukocytes.
follicular B cells
The majority population of long-lived recirculating conventional B cells found in the blood, the spleen, and the lymph nodes. Also known as B-2 B cells.
formed elements
Erythrocytes, leukocytes, and platelets within blood.
free (wandering) macrophage
A macrophage that leaves the blood and migrates to infected tissue.
Hematogenous spread
Spread of virus particles through the bloodstream. (Chapter 2)
hematoma
(hē-mă-tō′mă) Mass of blood outside of the blood vessels; e.g., subdural hematoma.
hematopoietic stem cells (HSCs)
Type of pluripotent cell in the bone marrow that can give rise to all the different blood cell types.
hemocytoblast
(hē′mō-sı̄′tō-blast) Immature cells in red bone marrow that produce all types of formed elements in blood.