White Cells: 6.8: Plasma Cell Disorders Flashcards
1
Q
What cytokine is elevated in multiple myeloma?
A
IL-6
2
Q
What cytokine activates osteoclasts?
A
IL-3, RANK-L, osteoclast activating factor
3
Q
What is the cause of the M spike in multiple myeloma?
A
usu. IgG or IgA
4
Q
What is the cause of the M spike in Waldenstrom macroglobulinemia?
A
IgM
5
Q
What RBC finding is seen in multiple myeloma?
A
Rouleaux formations
6
Q
What kind of amyloidosis is seen in multiple myeloma?
A
primary AL amyloidosis
7
Q
What is the name for free light chain excreted in the urine?
A
Bence-Jones protein
8
Q
Dx?
high serum protein with M spike on SPEP but no other s/s
A
MGUS
9
Q
How does Waldenstrom macroglobulinemia present?
A
generalized lymphadenopathy, increased serum protein –> hyperviscosity symptoms and bleeding
