Endocrine: 15.11: Adrenal Medulla Flashcards
The adrenal medulla is composed of _____ derived from _____.
- chromaffin cells
- from neural crest cells
How does pheochromocytoma look grossly?
a brown tumor of the adrenal medulla
Is pheochromocytoma benign or malignant?
usu. benign (90% of the time)
Name 2 neurocutaneous disorders assoc. with pheochromocytoma.
- Neurofibromatosis type 1
- von Hippel-Lindau disease
What is phentolamine? What is it used to treat?
- a reversible nonselective alpha blocker
- used to treat pts on MAOIs that have tyramine reaction
This drug is a reversible nonselective alpha blocker used to treat pts on MAOIs that have tyramine reaction.
phentolamine
What are the s/s of pheochromocytoma?
- episodic HTN
- HA
- palpitations
- tachycardia
- sweating
This drug is a nonselective, irreversible alpha blocker used pre-op in pheochromocytoma to prevent catecholamine (hypertensive) crisis.
phenoxybenzamine
Name a selective alpha-2 blocker. What is it used to treat?
- Mirtazapine
- it’s an atypical antidepressant
Other than the kidney, where else can pheochromocytomas occur?
the bladder wall
What is a pheochromocytoma?
a tumor of the chromaffin cells of the adrenal medulla
Mutation causing this disease?
- café-au-lait spots
- cutaneous neurofibromas
- optic gliomas
- pheochromocytomas
- Lisch nodules
- mutation of NF1 gene on Ch. 17
- disease = Neurofibromatosis Type 1
What is phenoxybenzamine? What is it used to treat?
- a nonselective, irreversible alpha blocker
- used pre-op in pheochromocytoma to prevent catecholamine (hypertensive) crisis
Which MEN subtypes are assoc. with pheochromocytoma?
- MEN 2A
- MEN 2B
This is a tumor of the chromaffin cells of the adrenal medulla.
pheochromocytoma
