Inflammation 2.5: Wound Healing

Question 1

What is the stem cell of the bone marrow? What’s its marker?

Answer 1

hematopoietic stem cells; CD34+

Question 2

Where are the small and large bowel stem cells located?

Answer 2

in the mucosal crypts

Question 3

What is the stem cell of the lung?

Answer 3

type II pneumocytes

Question 4

Where are the skin stem cells located?

Answer 4

in the basal layer

Question 5

What does type I collagen form?

Answer 5

bone (bONE)

Question 6

What does type II collagen form?

Answer 6

cartilage (carTWOlage)

Question 7

What does type III collagen form?

Answer 7

pliable structures

Question 8

What does type IV collagen form?

Answer 8

basement membranes

Question 9

What is the initial composition of granuloma tissue? What replaces is?

Answer 9

type III collagen –> type I collagen via collagenase and ZINC

Question 10

Why is wound healing delayed with vitamin C deficiency?

Answer 10

collagen can’t strengthen via hydroxylation

Question 11

Why is wound healing delayed with zinc deficiency?

Answer 11

lysyl oxidase cannot form collagen cross-links for strength

Question 12

Why is would healing delayed with copper deficiency?

Answer 12

type III collagen cannot be converted to type I collagen w/o zinc

Question 13

What kind of collagen is present in excess in a keloid scar?

Answer 13

type III collagen