Female Repro: 13.3: Cervix Flashcards
1
Q
What does E6 protein in HPV do?
A
destroys p53
2
Q
What does E7 protein in HPV do?
A
destroys Rb
3
Q
What does p53 do?
A
regulates G1-S transition; if there is too much DNA damage, p53 will induce apoptosis
4
Q
If there’s too much DNA damage at the G1-S transition, p53 will call in which molecule to begin apoptosis?
A
bax
5
Q
What molecule does Bax inhibit during apoptosis initiation?
A
BCL2
6
Q
What does BCL2 do?
A
stabilizes the mitochondrial membrane
7
Q
What happens when BCL2 is inhibited?
A
cytochrome C spills out of the mitochondria –> apoptosis occurs
