Pulmonary: 9.6: Pulm HTN

Question 1

Who classically gets 1a pulm HTN?

Answer 1

young adult females

Question 2

What is the normal pulmonary circuit pressure?

Answer 2

10mmHg

Question 3

How does pulm HTN present?

Answer 3

• exertional dyspnea
• RH failure

Question 4

What can cause increased volume in the pulmonary circuit?

Answer 4

congenital heart disease (Eisenmenger’s Syndrome)

Question 5

Thickening of the vascular smooth muscle cells of the lungs leads to _____.

Answer 5

pulm HTN

Question 6

What causes 2a pulm HTN?

Answer 6

1. hypoxemia
2. increased pulm circuit volume
3. recurrent PE

Question 7

What can PE cause?

Answer 7

1. nothing- asymptomatic
2. pulm infarction
3. sudden death (saddle emboli)
4. reorganization –> pulm HTN

Question 8

Pulmonary HTN is defined as pressure higher than ____.

Answer 8

25mmHg

Question 9

Pulm HTN leads to _____ and _____.

Answer 9

RV hypertrophy; cor pulmonale

Question 10

This is a group of capillaries swirled together- a complication of long standing pulm HTN.

Answer 10

a plexiform lesion

Question 11

What is cor pulmonale?

Answer 11

RH failure

Question 12

What causes 1a pulm HTN?

Answer 12

unknown etiology, but familial forms due to mutation in BMPR2

Question 13

What is a plexiform lesion?

Answer 13

a group of capillaries swirled together- a complication of long standing pulm HTN

Question 14

What are the characteristics of pulmonary HTN?

Answer 14

• atherosclerosis of the pulm trunk
• smooth muscle hypertrophy of pulm a.’s
• intimal fibrosis
• plexiform lesions

Question 15

What does a BMPR2 mutation cause?

Answer 15

1a pulm HTN via vascular smooth muscle proliferation