Skin: 19.2: Blistering Dermatoses Flashcards
Pemphigus vulgaris is the autoimmune destruction of ____.
desmosomes
In what layer are desmosomes found?
in the stratum spinosum
What kind of antibody is seen in Pemphigus vulgaris?
an IgG antibody against desmoglien surrounding the keratinocytes
What is acantholysis?
separation of keratinocytes
What connects the basal cell to the basement membrane?
hemidesmosomes
an IgG antibody against desmoglien surrounding the keratinocytes
Pemphigus vulgaris
Where do the blisters in Pemphigus vulgaris occur?
in the skin and mucosa
What do hemidesmosomes do?
connect the basal cells to the basement membrane
What kind of antibody is seen in Bullous Pemphigoid?
IgG Ab against the basement membrane (hemidesmosomes)
Where does Bullous Pemphigoid occur in the body?
on the skin only (no mucous membranes)
Do the bullae rupture easily in Bullous Pemphigoid or Pemphigus vulgaris?
Pemphigus vulgaris, bc they are thin-walled
What is the Ab in Dermatitis Herpetiformis?
IgA at the tips of the dermal papillae
What skin disease is often seen in Celiacs disease?
Dermatitis Herpetiformis
What does Dermatitis Herpetiformis look like?
grouped, Herpes-like vesicles that itch
What is Erythema Multiforme?
a hypersensitivity rxn with a target rash and bullae assoc. with HSV
