Endocrine: 15.2: Hyperthyroidism Flashcards
In hyperthyroidism, what does increased synthesis of Na+/K+/ATPase cause?
increased basal metabolic rate
This is when GAGs accumulate on the tibia (due to autoantibody to TSH receptor –> overstimulate fibroblasts –> secrete excess GAGs).
pretibial myxedema
What is a toxic goiter?
enlarged thyroid gland that becomes independent of TSH (toxic goiter)
What is Propylthiouracil (PTU)? What is it used to treat?
- inhibits peroxidase-mediated oxidation, organification, and coupling, and peripheral T4 –> T3 conversion
- tx for hyperthyroidism and thyroid storm
Why does hyperthyroidism cause hyperglycemia?
thyroid hormone causes gluconeogenesis and glycogenolysis
This drug inhibits peroxidase-mediated oxidation, organification, and coupling, and peripheral T4 –> T3 conversion.
Propylthiouracil (PTU)
What is the tx for Graves disease?
- beta-blockers
- thioamide
What is the tx for thyroid storm?
- Propylthiouracil (PTU)
- beta-blockers
- steroids
How does hyperthyroidism cause sympathetic nervous system activity?
increased expression of beta-1 adrenergic receptors
Dx?
- “dough-like” consistency over the anterior tibia
pretibial myxedema
Dx?
- scalloping of the colloid
Graves disease
This drug is a thyroid peroxidase inhibitor used as a tx for hyperthyroidism/graves.
thioamide
Why does hyperthyroidism cause hypocholesterolemia?
thyroid hormone causes increased LDL receptors in the liver
What is pretibial myxedema? How does this occur?
when GAGs accumulate on the tibia due to autoantibody to TSH receptor –> overstimulate fibroblasts –> secrete excess GAGs
How does hyperthyroidism cause increased basal metabolic rate?
increased synthesis of Na+/K+/ATPase
