Inflammation 2.4: Autoimmune Dz.

Question 1

What kidney problem is seen in SLE?

Answer 1

most common = diffuse proliferative glomerulonephritis

Question 2

What is Libman-Sacks endocarditis? What’s is assoc. with?

Answer 2

vegetations on both sides of a heart valve (composed of deposition and inflammation)

Question 3

What labs are diagnostic for SLE?

Answer 3

ANA, anti-dsDNA, anti-phospholipid ab (anticardiolipin and lupus anticoagulant)

Question 4

Name 3 drugs that can cause drug-induced SLE.

Answer 4

hydralazine, procainamide, and isoniazid

Question 5

What Ab is characteristic of drug-induced SLE?

Answer 5

anti-histone Ab

Question 6

In what disease can a false-positive syphilis test occur?

Answer 6

SLE

Question 7

What causes Budd-Chiari syndrome?

Answer 7

hepatic vein embolism

Question 8

What kind of hypersensitivity rxn is Sjogren syndrome?

Answer 8

type IV

Question 9

What are the characteristic lab findings in Sjogren syndrome?

Answer 9

ANA, anti-SS-A or SS-B (Sjogren-Syndrome)

Question 10

What is the target of the antibodies in Sjogren syndrome?

Answer 10

anti-ribonucleoprotein

Question 11

Sjogren syndrome has an increased risk of? How does it present?

Answer 11

B-cell lymphoma; unilateral enlargement of 1 parotid gland

Question 12

What lab findings are characteristic of scleroderma?

Answer 12

ANA, anti-DNA-topoisomerase I (Scl-70)

Question 13

What is the most common symptom in scleroderma?

Answer 13

dysphagia for solids and liquids

Question 14

What is the classic mnemonic for scleroderma?

Answer 14

CREST
Calcinosis/anti-Centromere Ab
Raynaud
Esophageal dysmotility
Sclerodactyly (esp hands)
Telangiectasias of skin

Question 15

What lab findings are characteristic of mixed CT disease?

Answer 15

anti-U1 ribonuceloprotein