Thyroid Disorders

Question 1

Levothyroxine (L-Thyroxine)

Answer 1

Thyroid disorders
-time to steady state 4-8 weeks
Therapeutic
-Hypothyroidism (drug of choice!)
MOA
-100% synthetic T4 (T4 receptor agonist)

Question 2

Methimozale

Answer 2

Thyroid disorders
-longer duration of action and fewer ADE (?)
Therapeutic
-Hyperthyroidism
-tx for Graves
-tx for pts undergoing thyroidectomy
MOA
-inhibit production of thyroid hormone (#1)
ADE
-polyarthritis
-cholestatis
-agranulocytosis

Question 3

Propylthiouracil (PTU)

Answer 3

Thyroid disorders
-must monitor CBC and liver fx test
Therapeutic
-hyperthyroidism
-thyroid storm (preferred tx)
-during 1st trimester of pregancy
-secondary to methimozale
MOA
-inhibits production of thyroid hormones (#2)
-inhibits peripheral T4 to T3 conversion
ADE
-severe liver injury
-acute liver failure
-ANCA + vasculitis
-hepatitis

Question 4

Amiodarone + Lithium

Answer 4

Thyroid disorders

• drug induced thyroid disease
  
  • lithium- for bipolar disorder, can cause hypo (more common) and hyper thyroidism
  • amiodarone- can cause hypo and hyper thyroidism