Ergogenic Drugs

Question 1

Anabolic-Androgenic Steroids (AAS)

Answer 1

Ergogenic Drugs
• derived synthetically from testosterone
• sex hormone stimulates:
o *Male sex characteristics
o *Growth in muscle and bones
• *Anabolic = muscle-building
• *Androgenic = increased male sexual characteristics
• *Cycling pattern = few weeks on drug, few weeks off drug. Or may use diff types of drugs to increase athletic performance
ADE
- increased BP
- decreased myocardial fn
o Males: decreased sperm count, testicular atrophy, impotence
o Females: menstrual irregularities, masculinization
o Other: male-pattern baldness, mania/depression/aggressin, mood swings

Question 2

Creatine

Answer 2

Ergogenic Drugs
- possibly effective for improving the athletic performance of young, healthy people during brief, high-intensity exercise such as sprinting (or weightlifting)
MOA
- Important a.a. that shuttles phosphate in skeletal muscle
- primary source of energy is ATP, phosphocreatine can shuttle phosphate–>add to ADP–>synthesize ATP. So more source of energy for use by muscle
ADE
- *Nephritis
- nausea/diarhea
- cramps/aches

Question 3

Human Growth Hormone

HGH

Answer 3

Ergogenic Drugs
- Athletes take recombinant human growth hormone because of its demonstrated effects on body composition (more muscle, less fat)
- Clinical trial data suggest that while lean body mass may be increased by growth hormone use, strength and exercise capacity is not. 
ADE
• *Nerve, muscle, or joint pain
• *Cardiomyopathy (severe)
• *Abnormal shaped head
• Swelling due to fluid in the body's tissues (edema)
• *Impaired glucose regulation (severe)
• *Carpal tunnel syndrome
• *Numbness and tingling of the skin
• *High cholesterol levels (severe)