NSAIDS

Question 0

Aspirin
Ibuprofen
Naproxen

Answer 0

• non selective COX inhibitor
• take aspirin (irreversibly inhibits COX1=decrease risk of blood clots)before you tak Ibuprofen (binds reversibly)
• Reyes Syndrome (unique to Aspirin)=encephalopathy, hepatic dysfunction
• COX1 (constitutional)-cytoprotective prostaglandins=protects gastric mucosa but increases platelet aggregation
• inhibition leads to GI toxicity; decrease risk by concurrently using proton pump inhibitors (decrease acid in stomach)

Question 1

NSAIDS

Answer 1

• non steroidal anti-inflammatory drugs
• Goal: to prevent inflammation
• MOA: inhibit cycloOxygenase (COX) aka prostaglandin synthesis

Question 2

Celecoxib

Answer 2

• selective COX2 inhibitor
• COX-2 (inducible)=inflammatory prostaglandins=recruits inflammatory cells, sensitize skin pain receptors, cause fever
• Inhibition=COX1 causes platelet aggregation and without balance, increase risk of cardiovascular events

Question 3

Acetaminophen

Tylenol

Answer 3

• it is NSAID

- different MOA than COX inhibitors, not anti-inflammatory