Constipation Flashcards
Psyllium
Constipation Bulk forming Laxatives MOA -hydrophilic colloids absorb water, increases bulk and peristalsis ADE •Diarrhea, bloating, flatus
Docusate Sodium/Calcium
Constipation
stool softener
MOA
-Allow increased absorption of lipids and water into stool.
Lubiprostone
Constipation
Chloride Channel Activators
Therapeutic
-Chronic constipation and Irritable bowel syndrome
MOA
-Activate type-2 chloride channels in small intestine, increases motility and decreases intestinal transit times
ADE
•Return of constipation to pretreatment severity
•Nausea in 30% of patients
Magnesium Hydroxide
Constipation Osmotic Laxatives Therapeutic -acid peptic disorders, dyspepsia, acute/prevent constipation MOA -increase liquidity of stool via increase more water absorption in the colon Contraindications -patients with renal insufficiency
Lactulose
Constipation Osmotic Laxatives Therapeutic -prevent/treat constipation MOA -increase liquidity of stool via increase more water absorption in the colon ADE •Severe flatus and cramps
Magnesium Citrate, Sodium Phosphate
Constipation
Osmotic Laxatives/Purgatives
Therapeutic
-Acute constipation and Cleanse Bowels (colonoscopy)
MOA
-increase liquidity of stool via increase more water absorption in the colon
ADE
•Increase *Phosphate, sodium, *calcium.
•Decrease in potassium
Contraindication
•Elderly, cardiac disease, renal insufficiency
Polyethylene Glycol
Constipation
Osmotic Laxative
Therapeutic
-Bowel Cleansing, prevent/treat chronic constipation
MOA
-increase liquidity of stool via increase more water absorption in the colon
Senna
Constipation Stimulant laxative Anthraquinone Derivatives MOA -poorly understood -stimulation of enteric nervous system colonic electrolyte and fluid secretion Adverse Effects •Chronic use = brown pigmentation of colon “melanosis coli”
Bisacodyl
Constipation Stimulant laxative Diphnylmethane Derivatives Therapeutic -Acute/Chronic constipation, and used with PEG (or without) for colonic cleansing MOA -poorly understood -stimulation of enteric nervous system colonic electrolyte and fluid secretion
Magnesium Hydroxide, Aluminum Hydroxide
Constipation Stimulant laxative Antacids Therapeutic -for dyspepsia MOA React with HCL to form magnesium/aluminum chloride + water (neutralization) Adverse Effects •Aluminum hydroxide – constipation •Magnesium hydroxide – diarrhea
Simethicone
Constipation
Stimulant laxative
Therapeutic
-used for anti-gas
-extra belching, bloating, and pressure/discomfort in stomach/gut
MOA
-defoaming action breaks up gas in the intestine
