Angina

Question 0

Verapamil
Diltiazem
Nifedipine
Amlodipine

Answer 0

-“-dipine”
-calcium channel blocker
-used for stable, variant, unstable angina
-leads to reduction in contractility
MOA
-DEC influx of Ca2+ from L-type calcium cannels
ADE
-cardiac depresion, cardiac arrest, bradycardia, AV block, heart failure
-flushing, dizziness, nausea, constipation, edema

Question 1

Nitroglycerin

Isosorbide mononitrate/di-nitrate

Answer 1

-nitrates
-DEC preload and afterload, INC myocardial O2 supply
-used for stable, exertional, variant, and unstable angina
MOA
-activates guanyly cyclase
-INC cGMP
-dephosphorylation of mysoin-LC
ADE
-orthostatic hypotension, tachycardia, HA, tolerance
Contraindications
-intracranial pressure is elevated
-*PDE5 inhibitors

Question 2

Propranolol
Atenolol
Metoprolol

Answer 2

-“-olol”
-beta-blockers
-used for stable and unstable angina
Effect on beta1-blockers
-DEC HR
-DEC contractility
-DEC nerve conduction
Effect on beta2-blockers
-bronchoconstriction
-vasoconstriction
MOA
-bock sympathetic activation at the post synaptic membrane
ADE
-bradycardia
-CNS: depression, mood changes, dizziness, lethargy
Contraindications
-asthma and other vasospastic conditions
-severe bradycardia-tachycardia syndrom
-severe unstable ventricular blockade