Renal Failulre Flashcards
0
Q
*Losartan
Candesartan, Eprosartan, Olmesartan
A
Renal failure -"-sartan" -Angiotensin receptor-blockers (ARBs) Goals -DEC BP and DEC urine protein MOA -block Ang II type 1 (AT1) receptors -DEC PVR ADE -hyperkalemia
1
Q
*Enalapril, *Lisinopril
Benazepril, Fosinopril, Ramipril
A
Renal Failure -"-pril" -Angiotensin-Converting enzyme (ACE) Inhibitor Goals -DEC BP and DEC urine protein MOA -inhibit peptidyl dipeptidase -inhibits plasma kininase which inactivates bradykinin (potent vasodilator) -DEC PVR ADE -hyperkalemia
2
Q
Sodium Polystyrene Sulfonate
A
Renal failure -used for hyperkalemia MOA -resin removes K ions in GI by replacing them w/ Na ADE -*GI distress (nausea, vomiting) -fecal impaction -Metabolic nutrition disorder -hypokalemia and hypocalcemia -retention of sodium Contraindications -serum K < 5 mmol/L -obstructive bowel disease
3
Q
Sodium Bicarbonate
A
Renal failure
-used for metabolic acidosis (agent of choice!)
4
Q
Calcium Carbonate/Acetate
A
Renal failure -Phosphate binder -used for hyperphosphatemia -used for hypocalcemia ADE -GI effects -hypercalcemia -soft tissue calcification, suppress PTH
5
Q
Sevelamamer Carbonate
A
Renal Failure -Phosphate binder -used for hyperphosphatemia -DEC LDL-C (not importatn) ADE -bowel obstruction and perforation -GI effects
6
Q
Lanthanum
A
Renal failure -Phosphate binder -used for hyperphosphatemia ADE -accumulation of lanthanum -GI effects
7
Q
Vitamin D Agents
*Calcitriol, *Doxercalciferol, *Paricalcitol, Cholcalciferol, Ergocalciferol
A
Renal failure -Vitamin D agents -used for hyperparathyroidism MOA -provide calcitriol ADE -hypercalcemia -hyperphosphatemia
8
Q
Cinacalcet
A
Renal failure -used for secondary hyperparathyroidism (HPT) w/ CKD on dialysis -is an allosteric activator MOA -INC sensitivity of Ca of CASR on parathyroid gland (so PTH will be sent out less->reduce extraction of Ca from bone) ADE -GI effects - nausea, vomiting, diarrhea Contraindications -hypocalcemia Drug interactions -inhibitor of CYP3A4 and CYP2D6
