Analgesics

Question 0

Bupivacaine

Answer 0

-“-caines”
-Local anesthetic
MOA: PRE-DEC Ca influx=DEC NT release; POST-Cl influx/K outflow=hyperpolarization=no AP
ADE
-can cause CNS excitation, seizure, CV collapse

Question 1

Lidocaine

Answer 1

-local anesthetic
MOA: PRE-DEC Ca influx=DEC NT release; POST-Cl influx/K outflow=hyperpolarization=no AP
ADE
-can cause CNS excitation, seizure, CV collapse

Question 2

Morphine

Answer 2

-opioid analgesic
-pure opioid agonist
-strong+++
MOA: Mu and Kappa receptor agonist
-PRE-DEC Ca influx=DEC NT release; POST-Cl influx/K outflow=hyperpolarization=no AP
-induces NE and serotonin in pain inhibitory neuron
ADE
-nausea, vomitting, respiratory depression, sedatative, hypnotic effect constipation, urticaria (rash), pruritus (itch), bronchospasms

Question 3

Fentanyl

Answer 3

-opioid analgesic
-strong+++
MOA: Mu receptor agonist
-PRE-DEC Ca influx=DEC NT release; POST-Cl influx/K outflow=hyperpolarization=no AP
-induces NE and serotonin in pain inhibitory neuron
ADE
-nausea, vomitting, respiratory depression, sedatative, hypnotic effect constipation, urticaria (rash), pruritus (itch), bronchospasms

Question 4

Hydromorphone

Answer 4

-opioid analgesics
-strong+++
MOA: Mu receptor agonist
-PRE-DEC Ca influx=DEC NT release; POST-Cl influx/K outflow=hyperpolarization=no AP
-induces NE and serotonin in pain inhibitory neuron
ADE
-nausea, vomitting, respiratory depression, sedatative, hypnotic effect constipation, urticaria (rash), pruritus (itch), bronchospasms

Question 5

Hydrocodone

Answer 5

-Opioid analgesics
MOA: Mu receptor partial agonist
-PRE-DEC Ca influx=DEC NT release; POST-Cl influx/K outflow=hyperpolarization=no AP
-induces NE and serotonin in pain inhibitory neuron
ADE
-nausea, vomitting, respiratory depression, sedatative, hypnotic effect constipation, urticaria (rash), pruritus (itch), bronchospasms

Question 6

Oxycodone

Answer 6

-Opioid analgesic
-strong++
MOA: Mu receptor agonist
-PRE-DEC Ca influx=DEC NT release; POST-Cl influx/K outflow=hyperpolarization=no AP
-induces NE and serotonin in pain inhibitory neuron
ADE
-nausea, vomitting, respiratory depression, sedatative, hypnotic effect constipation, urticaria (rash), pruritus (itch), bronchospasms

Question 7

Naloxone

NARCAN

Answer 7

• pure opioid antagonist
• Opioid OD antidote
• blocks Mu and Kappa receptors

Question 8

Tramadol

Answer 8

-Opioid analgesic
MOA: weak Mu receptor agonist
–PRE-DEC Ca influx=DEC NT release; POST-Cl influx/K outflow=hyperpolarization=no AP
-induces NE and serotonin in pain inhibitory neuron
ADE
-nausea, vomitting, respiratory depression, sedatative, hypnotic effect constipation, urticaria (rash), pruritus (itch), bronchospasms