TB

Question 0

Rifampin

RIF

Answer 0

TB
MOA
-inhibits RNA synthesis
ADE
-*hepatitis (inducers of hepatic CYP enzymes 3A457)
-*sig interactions w/ other drugs
-*orange color in urine, feces, saliva, sputum w/ overusage
-*"red man syndrome"
-GI issues
-rash
-flue-like syndrome

Question 1

Isoniazid

INH

Answer 1

TB
MOA
-inhibits cell wall synthesis (via inhibition of mycolic acid synthesis and catalase peroxidase enzyme)
ADE
-*hepatic enzyme elevation
-*hepatitis
-*peripheral neuropathy
  -pyridoxine supplement recommended to prevent neuropathy
  -greater risk: ppl w/ nutritional deficiency, diabetes, HIV, renal failure, alcoholics, pregnant breasfeeding women
Contraindications
-phenytoin
-antifungal agents (azole)

Question 2

Ethambutol

EMB

Answer 2

TB
MOA
-inhibits cell wall synthesis (via blocking arabinosyl transferase)
ADE
-optic neuritis w/ blurred vision
-red-green color blindness

Question 3

Pyrazinamide

PZA

Answer 3

TB
MOA
-disrupts plasma membrane
-disrupts energy metabolism
ADE
-*hepatitis
-nausea
-hyperuricemia
-rash
-joint ache
-gout (rare)