DM

Question 1

Fast acting injectable insulin

Lispro, Apart, Glulisine=analog

Answer 1

DM
-preferred form home insulin pumps; can be given IV
-usu used for mealtime and correction insulin dosage
MOA
-onset=less than 15 min
-peak=1 hr
-duration=4 hrs

Question 2

Short acting injectable insulin

regular U-100

Answer 2

DM
-can be given IV
MOA
-onset=30-60 min
-peak=2-4 hrs
-duration=5-8 hrs

Question 3

Intermediate acting injectable insulin

Neutral protamine hagerdorn (NPH)

Answer 3

DM
-cloud suspension
MOA
-onset=1-3 hrs
-peak=6-12 hrs
-duration=14-24 hrs

Question 4

Long acting injectable insulin

Glargine, Detemir=analog

Answer 4

DM
-Glargine=forms insulin microdeposit at injx site
-Detemir=highly bound to albumin in tissues and blood
-Note: usu used for basal insulin dose
MOA
-onset=1-2 hrs
-peak=flat
-duration=24 hrs

Question 5

Special injectable insulin

Regualr U-500

Answer 5

DM
MOA
-onset=30min
-peak=2-4 hrs
-duration=12-24 hrs

Question 6

Rescue meds for hypoglycemia

Glucagon, dextrose 50

Answer 6

DM

• Glucagon=via IM
• Dextrose 50=”IV” use only; too hypertonic for IM or subcutaneous adm

Question 7

Insulin

Answer 7

DM
Therapeutic use
-glycemic control (type1 and 2 DM, gestational diabetes, other DM causes, hospital hyperglycemia during stressful events)
-hyperkalemia-acute tx using regular insulin w/ 50% dextrose IV
ADE
-hypoglycemia
-allergy
-lipodystrophy (prevent by rotating injx sites)