MSSA, MRSA

Question 0

Penicillin G

Answer 0

• natural penicillins
• against group A strep
• binds to penicillin binding protein and destroys crosslinking

Question 1

Probenecid

Answer 1

-blocks tubular secretion (URAT1), which prolongs elimination half life of penicillin

Question 2

Penicillin V

Answer 2

• natural penicillins
• against group A strep
• binds to penicillin binding protein and destroys crosslinking

Question 3

Oxacillin
Nafcillin
Dicloxacillin

Answer 3

• Beta-lactamase resistant
• MSSA
• binds to penicillin binding protein and destroys crosslinking
• resistant to cutting of Beta-lactamase

Question 4

Ampicillin

Amoxicillin

Answer 4

• Aminoenicillins

- Gr-, limited

Question 5

Piperacillin (w/tazobactam)

“pip-tazo”

Answer 5

• extended spectrum penicillins
• only available with beta-lactamase inhibitor
• can cause C. diff

Question 6

Vancomycin

Answer 6

• variable penicillin receptor
• MRSA
• ok to give with beta-lactam allergy
• MOA: doesn’t bind to penicillin binding protein, binds to ALA-ALA on peptide chain
• resistance-D-lactate replaces alanine on NAM peptide, prevents binding of Vancomycin
• effect: red man syndrome, C. Diff destruction