DMARDS Flashcards
0
Q
Corticosteroids
A
- used w/ DMARDs
- can be disease modifying
- used for inflammatory disorders/autoimmune disorders
- can cause Cushing’s Syndrome=peds growth retardation
1
Q
DMARDs
A
- Disease modifying anti-rheumatic drugs
- Main target=TNF-alpha, to decrease inflammation
- used along w/ NSAIDS and corticosteroids
2
Q
NSAIDS
A
- non-steroidal anti-inflammatory drug
- used with DMARDs
- not disease modifying
- reduce pain and inflammatory response
3
Q
Monoclonal Antibody
A
- “-mab”
- biologic DMARDs
- made from murine rodent antibodies
- custom make antibody to bind to ligand or receptor
- Xenomouse produces human IgG
- INC risk of TB, fungal/viral infection, malignancy, and hypersensitivity rxns
4
Q
Fusion Protein
A
“-cept”
- biologic DMARDs
- fc portion of IgG+receptor
- MOA ligand binds to decoy receptor
- ex. Etanercept binds to TNF-alpha
- ex. Abatacept binds to CD80/86
- INC risk of TB, fungal/viral infection, malignancy, and hypersensitivity rxns
5
Q
Methotrexate
MTX
A
- conventional DMARDs
- MOA (general) inhibition of tetrahydrofolate (folic acid)=inhibits DNA+RNA synthesis
- MOA (RA) promote adenosine release (anti-inflammatory mediator)
- ADV GI intolerance, bone marrow suppression, liver cirrhosis
6
Q
Lelfunomide
A
- conventional DMARDs
- MOA DEC lymphocyte proliferation by inhibiting dihydrooratoate dehydrogenase (DHODH)=suppress the de novo synthesis of pyrimidine nucleotides
- ADV long half life, so drug elimination is necessary for women who want baby
7
Q
Kinase inhibitor
A
- biologic DMARDs
- “-nib”
- MOA: kinase inhibition=stop signal transduction pathway
