Pituitary Disorders Flashcards
1
Q
(Octreotide)
A
Pituitary disorders -Somatostatin analog -limited therapeutic effect Therapeutic -DEC symptoms of hormone-secreting tumors: *acromegaly, carcinoid syndrome, glucagonoma -used to locate neuroendocrine tumors MOA -inhibit release of GH, TSH, glucagon, insulin and gastrin ADE -GI effects, N/V -cardiac effects -Tx>6 months-bilary sludge and gallstones -Tx>12 months-Vit B12 deficiency
2
Q
Cabergoline, Bromocriptine
A
Pituitary disorders -dopamine agonist: ergot derivatives -cabergoline is better, less ADE Therapeutic -*hyperprolactinemia (1st line therapy!) -Acromegaly -can use for parkinsons, but not widely used MOA -D2 agonist ADE -nausea, HA -orthostatic hypotension, fatigue Contraindications -small adenomas during pregnancy -if large, then use
3
Q
Posterior Pituitary
=GH + prolactin
A
MOA
-JAK-STAT pathway–> regulate gene transcription
