GBS in Pregnancy

Question 1

Penicillin G, Ampicillin, Cefazolin

Answer 1

GBS in pregnancy
Β-LACTAM ANTIBIOTICS
Penicillin group:
   - Penicillin G
   - Ampicillin
Cephalosporin Group:            - Cefazolin
MOA
- β-Lactam-ring inhibits synthesis of the peptidoglycan layer (outermost and primary component of the wall) important for cell wall structural integrity, especially in G+
ADE
•Risk of Cross-sensitivity  
•Allergic Reactions of B-Lactams.

Question 2

Clindamycin

Answer 2

GBS in pregnancy
Therapeutic
-Group A & B Strep,
-Staphaureus (MRSA, MSSA),
-some Anaerobes, esp Gr- Bacteroides Fragilis
MOA
- β-Lactam-ring inhibits synthesis of the peptidoglycan layer (outermost and primary component of the wall) important for cell wall structural integrity, especially in G+

Question 3

Vancomycin

Answer 3

GBS in pregnancy
MOA
- Different than β-Lac’s. 
Therapeutic
-G+ Aerobes: Staph & Strep (GBS!)
-G+ Anaerobes: C. Diff.