Diarrhea Flashcards
1
Q
Fidaxomicin
A
Diarrhea
Therapeutic
-used to tx CDAD
2
Q
*Dicylomine, *Hycosyamine, Atropine
A
Diarrhea Anticholinergics Therapeutic -used to tx irritable bowel syndrome MOA -Decrease GI motility -Decrease GI secretions -Antispasmodic ADE -Dry mouth -Constipation -Confusion, cognitive problems -Blurred vision -Urinary retention w/ males “Mad as a hatter, Red as a beet, Blind as a bat, Hot as a hare, Dry as a bone.”
3
Q
Loperamide (OTC), Diphenoxylate/Atropine, Opium
A
Diarrhea Opioids Therapeutic -anti-diarrheal MOA -Act primarily on GI opioid receptors (mµ) to decrease GI motility and secretions ADE -little to know CNS effects -addiction
4
Q
Bismuth Subsaliclate (PeptoBismol–OTC)
A
Diarrhea Subsalicylate Therapeutic -anti-diarrheal MOA -anti-secretory, anti-inflammatory, antimicrobial -Reacts with gastric HCl to form bismuth oxychloride and salicylic acid ADE -Dark stools -Black- stained tongue -Elevated anion gap metabolic acidosis
5
Q
Mesalamine
prodrugs (Sulfasalazine, Olsalazine, Balsalazide)
A
Diarrhea 5- ASA=5 amino salicylic acid=mesalamine Therapeutic -used to tx Inflammatory bowel disease (UC, chrons) MOA -down-regulation of NF-κB activity ADE -Headache -Nausea -Skin rash
