Anti-helminths

Question 1

Pyrantel pamoate

Answer 1

Anti-helminths
•Alternative tx for pinworm
•Available OTC
MOA
•*Causes worm paralysis and removal by gut peristalsis
•Agonist at nicotinic acetylcholine receptors and acts as depolarizing neuromuscular blocking agent

Question 2

*Albendazole, Mebendazol

Answer 2

Anti-helminths
•DOC for pinworm
•DOC for Neurocistercercosis (give with Praziquantel) caused Taenia solium (pork tapeworm)
•DOC for Toxocariasis = dog or cat roundworm (Toxocara canis, Toxocara cati)
MOA
•Causes inability to uptake glucose by the larva and adult
•Causes degenerative alterations in the tegument and intestinal cells of the parasite by inhibiting its polymerization into microtubules

Question 3

Praziquantel

Answer 3

Anti-helminths
•DOC for tapeworm
•DOC for Neurocistercercosis (give with Albendazole)
MOA
•Does not kill cestodes in vivo, but causes the worms to dislodge from the intestinal wall.
•Disrupts the parasite tegument, causing tetanic contractures with loss of adherence to host tissues and, ultimately, disintegration or expulsion
•Exposes concealed antigens in the parasite