T and B Cell Suppressors

Question 1

Medications

Answer 1

• Cyclosporine: suppression of rejection in transplants; rheumatoid arthritis, psoriasis
• Azathioprine: Prevention of rejection in renal hemotransplants; rheumatoid arthritis
• Glatiramer: reduction in number of relapse in MS in adults
• Mycophenolate: prevention of rejection after renal or heart transplant in adults

Question 2

Actions

Answer 2

-Block antibody production by B cells, inhibit suppressor and helper T cells, and modify the release of interleukins and T cell growth

Question 3

Contraindications

Answer 3

• Allergy
• Pregnancy/lactation
• Hepatic disease

Question 4

Adverse effects

Answer 4

-Increased risk of infection and for the development of neoplasms due to blocking the immune system as well as hepatotoxicity, renal toxicity, renal dysfunction, and pulmonary edema

Question 5

Drug-drug

Answer 5

-Increased risk of toxicity if these drugs are combined with other drugs that are hepatotoxic or nephrotoxic