Colony-Stimulating Factors

Question 1

Medication

Answer 1

-Filgrastim

Question 2

Actions

Answer 2

• Increase the production of neutrophils in the bone marrow with little effect on other cells
• Can be used to reduce the incidence of infection in patients with bone marrow suppression, to decrease the neutropenia associated with bone marrow transplants and chemo, and to help in the treatment of various blood-related cancers

Question 3

Contraindications

Answer 3

• Allergy to any component of the drug
• Pregnancy/lactation
• Renal or hepatice disease
• Radiation and chemo

Question 4

Adverse effects

Answer 4

-GI related, headache, fatigue, generalized weakness, alopecia and dermatitis, and generalized pain and bone pain

Question 5

Drug-drug

Answer 5

-Increase in myeloproliferative effects of sargtamostim when combined with lithium or corticosteroids