Interleukins

Question 1

Medications

Answer 1

• Aldesleukin: human interleukin produced by recombinant DNA technology using E. Coli bacteria
• Oprelvekin: Newer agent produced by DNA technology

Question 2

Actions

Answer 2

• Chemicals normally produced by T cells to communicate between leukocytes
• Increase the number of natural killer cells and lymphocytes
• Activates cellular immunity and inhibits tumor growth

Question 3

Indications

Answer 3

• Aldesleukin: specific renal carcinomas; possible treatment of AIDs
• Oprelvekin: prevention of severe thrombocytopenia after myelosuppressive chemotherapy

Question 4

Contraindications

Answer 4

• Allergy

- Pregnancy/lactation

Question 5

Caution

Answer 5

-Renal, liver, or cardiovascular impairment

Question 6

Adverse effects

Answer 6

-Lethargy, myalgia, arthralgia, fatigue, fever, respiratory difficulties, depression with suicidal ideation