Histamine-2 (H2) Antagonists

Question 1

Medications

Answer 1

“-tidine”

• Cimetidine
• Ranitidine
• Famotidine

Question 2

Actions

Answer 2

• Block the release of hydrochloric acid in response to gastrin
• Selectively block histamine-2 receptor sites
• This blocking leads to a reduction in gastric acid secretion and reduction in overall pepsin production

Question 3

Indications

Answer 3

• Short-term treatment of active duodena ulcer or benign gastric ulcer
• Treatment of pathological hypersecretory conditions such as Zollinger-Ellison syndrome
• Prophylaxsis of stress-induced ulcers and acute upper GI bleeding
• Treatment or erosive GERD
• Relief of symptoms of heartburn, acid indigestion, and sour stomach

Question 4

Contraindications

Answer 4

-Allergy

Question 5

Caution

Answer 5

• Pregnancy/lactation

- Hepatic or renal dysfunction

Question 6

Adverse effects

Answer 6

• GI effects
• CNS effects
• Cardiac arrhythmias and hypotension

Question 7

Drug-drug

Answer 7

-Warfarin, phenytoin, beta-blockers, alcohol, quinidine, lidocaine, theophylline, chloroquine, benzodiazepines, nifedipine, pentoxifylline, tricyclics, procainamide, and carbamazapine

Question 8

Assessment

Answer 8

• History: Allery, contraindications or cautions

- Physical: VS, neuro status, cardiopulmonary status, abdominal assessment

Question 9

Nursing diagnoses

Answer 9

• Acute pain
• Disturbed sensory perception
• Risk for injury
• Decreased cardiac output
• Deficient knowledge

Question 10

Implementation

Answer 10

• Admin oral drugs with or before meals and at bedtime
• Decrease dose if hepatic or renal dysfunction
• Monitor closely if giving IV
• Assess carefully for adverse effects
• Provide comfort and safety measures
• Pt teaching

Question 11

Evaluation

Answer 11

• Patient response
• Effectiveness of teaching plan
• Effectiveness of comfort measures
• Compliance