Drugs Affecting GI Secretions - General

Question 1

Underlying causes of GI disorders

Answer 1

• Peptic ulcer disease
• Dietary excess
• Stress
• Hiatal hernia
• Esophageal reflux
• Adverse drug effects

Question 2

Effect of drugs on GI secretions

Answer 2

• Decrease GI secretory activity
• Block the action of GI secretions
• Form protective coverings on the GI lining to prevent erosion from GI secretions
• Replace missing GI enzymes

Question 3

Peptic ulcer disease

Answer 3

• Erosions in the lining of the stomach and adjacent areas of the GI tract
• S/S: gnawing, burning pain, often occuring after meals
• Cause: NSAIDs, bacterial infection by H. Pylori, Stress

Question 4

Drugs used to treat GERD and ulcers

Answer 4

• H2 antagonists: block the release of hydrochloric acid in response to gastrin
• Antacids: interact with acids at the chemical level to neutralize them
• Proton pump inhibitors: suppress the secretion of hydrochloric acid into the lumen of the stomach
• GI protectants: coat any injured area in the stomach to prevent further injury
• Prostaglandins: inhibit the secretion of gastrin and increase the secretion of the mucous lining of the stomach