Class I Antiarrhythmic Flashcards
1
Q
Medications
A
Ia: Disopyramide, procainamide, quinidine
Ib: Lidocaine, mexiletine
Ic: Flecainide, propafenone
2
Q
Action
A
-Decreases depolarization, decreasing automaticity of the ventricular cells; increases ventricular fibrillation threshold
3
Q
Indications
A
-Management of acute ventricular arrhythmias during cardiac surgery or MI
4
Q
Contraindications
A
- Allergy
- Bradycardia or heart block
- CHF
- Hypotension or shock
- Electrolyte depletion
5
Q
Caution
A
- Renal or hepatic dysfunction
- Pregnancy
6
Q
Adverse effects
A
- CNS: dizziness, fatigue, slurred speech
- GI: N/V
- CV: Arrhythmias
- Respiratory depression
- Misc: rash, loss of hair, and potential bone marrow suppression
7
Q
Drug-Drug interactions
A
- Quinidine & digoxin
- Oral anticoagulants
- Digoxin and beta- blockers
8
Q
Drug-Food interactions
A
- Foods that alkalinize the urine (citrus juice, vegetables, antacids, milk)
- Grapefruit juice
