Bile Acid Sequestrants Flashcards
1
Q
Medications
A
“chole-“ or “cole-“
- Cholestyramine
- Colestipol
- Colesevelam
2
Q
Action
A
-Binds to bile acids in the intestine, allows excretion in feces instead of reabsorption, serum cholesterol levels fall
3
Q
Indications
A
- Decrease in plasma cholesterol levels in primary hypercholesterolemia
- Pruritis associated with partial biliary obstruction
4
Q
Contraindications
A
- Allergy
- Complete biliary obstruction/abnormal intestinal function
- Pregnancy and lactation
5
Q
Adverse drug effects
A
- CNS: Headache, anxiety, fatigue, and drowsiness
- Direct GI irritation: Nausea, constipation
- Vitamin A,D,E,K deficiencies: Increased bleeding times
6
Q
Drug-Drug interactions
A
- Malabsorption of fat-soluble vitamins
- Affect absorption of other drugs
7
Q
Assessment
A
- History: Allergy, pregnancy/lactation, impaired intestinal fx or obstruction
- Physical: skin, CNS, GI system, vitals, weight
- Labs: cholesterol, lipid levels, clotting factors
8
Q
Nursing Diagnoses
A
- Acute pain
- Constipation
- Risk for injury
- Deficient knowledge
9
Q
Implementation
A
- Tablets cannot be cut or crushed
- Give drug BEFORE meals
- Administer other PO drugs 1 hr before or 4-6 hours after
- Arranged bowel program
- Comfort and safety measures for adverse effects
- Provide pt teaching
10
Q
Evaluation
A
- Evaluate response to drug
- Evaluate effectiveness of teaching plan
- Evaluate effectiveness of comfort and safety measures/compliance with regimen
