Nonsteriodal Anti-Inflammatory Drugs (NSAIDs)

Question 1

Medications

Answer 1

• Propionic Acids: Ibuprofen, Naproxen
• Acetic Acids: Indomethacin, Ketolorac
• Opium derivatives: Meloxicam
• Cyclooxygenase-2 Inhibitors: Celecoxib

Question 2

Actions

Answer 2

• Block two enzymes, known as COX-1 and COX-2
• Provide a strong anti-inflammatory and analgesic effect
• Anti-inflammatory, anti-pyretic, and anti-analgesic

Question 3

Contraindications

Answer 3

• Allergy to any NSAID or salicylate, and celecoxib is also contraindicated in the presence of allergy to sulfonamides
• CV dysfunction or HTN, peptic ulcer, GI bleed, pregnancy/lactation

Question 4

Cautions

Answer 4

-Renal or hepatic dysfunction

Question 5

Adverse effects

Answer 5

-Nausea, dyspepsia, GI pain, constipation, diarrhea, or flatulence caused by direct GI effects, GI bleed, dizziness, somnolence, platelet inhibition, HTN, and even bone marrow depression

Question 6

Drug-Drug

Answer 6

• Decreased diuretic effect when these are taken with loop diuretics
• Decreased antihypertensive effects of beta-blockers
• Reports of lithium toxicity when combined with ibuprofen

Question 7

Assessment

Answer 7

• History: allergy, contraindications or cautions

- Physical: skin lesions, VS, orientation and reflexes, perfusion, respirations and sounds, liver evaluation