Anti-Inflammatory/Anti-Arthritis Agents - General

Question 1

Inflammatory response

Answer 1

• Protects the body from injury and pathogens

- Uses chemical mediators to produce a reaction that helps destroy pathogens and promotes healing

Question 2

Anti-inflammatory agents

Answer 2

• Corticosteroids
• Antihistamines
• Immune-modulating agents

Question 3

Considerations for children

Answer 3

• More susceptible to GI and CNS effects
• Parents need to check OTC ingredients
• Salicylates should NOT be used for fever/viral infection due to risk or Reye syndrome
• Acetaminophen is most commonly used

Question 4

Considerations for adults

Answer 4

• Caution about OTC products

- Caution in pregnancy/lactation: Severe ADE on neonate and mother with salicylates, NSAIDs, and gold products

Question 5

Considerations for older adults

Answer 5

• More susceptible to ADE
• Dose adjustment may be needed
• Gold salts are toxic for older adults: if used, dose must be lowered and patient needs to be monitored closely for toxicity

Question 6

Arthritis

Answer 6

-Potentially debilitating inflammatory process

Question 7

Auranofin

Answer 7

• Treatment of selected adults with rheumatoid arthritis, who have insufficient response to or intolerance to NSAIDs
• Inhibits phagocytosis and release of lysosomal enzymes that cause damage associated with inflammation