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Ricketssia And Miscallaneous Bacteria Flashcards

1
Q

Ricketssiae features

A

Obligate intracellular organism
Cannot grow on artificial media
Grow in cell lines only

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2
Q

Ricketssiae infection is transmitted by

A

Arthropod borne transmission except Coxiella (inhalational)

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3
Q

Rash can be seen in all Ricketssial infections except

A

Coxiella

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4
Q

Pathogenesis of Ricketssial infections

A

Reservoir host - vector - humans - multiply locally and enter blood stream - localise at endothelium - degenerate and thrombosis - Occlusion

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5
Q

Epidemic typhus cause and transmitted by

A

R. Prowazekii
Louse

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6
Q

Endemic typhus cause and transmitted by

A

R. Typhi
Flea

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7
Q

Rocky mountain spotted fever cause and vector

A

R. Ricketsii
Tick

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8
Q

Cause of African tick typhus and vector

A

R. Conori
Tick

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9
Q

Cause of Ricketssial pox and vector

A

R. Akari
Mite

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10
Q

Scrub typhus is caused by and Vector

A

Orientia tsutsugamushi
Mite

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11
Q

Mnemonic of Ricketssial infections

A

LET - Louse epidemic typhus
FEN - Flea Endemic typhus
TRIA - Tick RMSF Indian tick and African tick typhus
PSM - Ricketssial pox, Scrub typhus, Mite

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12
Q

Louse features in case of Epidemic typhus

A

On fever, louse leaves body (sensitive to heat)
Not a zoonotic disease
Infection is transmitted by entry of Louse feces into body via abrasions

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13
Q

Incubation period of Epidemic typhus/Jail fever

A

5-15 days

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14
Q

Clinical features of Epidemic typhus

A

Fever , Chills
After 4-5 days, Rash first appear on trunk and then limbs - Delirious - fatal

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15
Q

All Ricketssial infections causes rash first on trunk and then limbs except

A

Rocky Mountain spot fever - starts from extremities then goes to trunk

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16
Q

Brill zinser disease is due to

A

Reactivation of Epidemic typhus
Less severe
No vector

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17
Q

Neil mooser reaction/Tunica reaction is shown by

A

R. Prowazekii - negative Reaction
R. Typhii (Endemic typhus) - Positive reaction

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18
Q

Procedure of Neil mooser reaction/Tunica reaction

A

Intraperitoneal inoculation of guinea pig with blood from case - Scrotal inflammation - +ve Reaction

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19
Q

Scrub typhus is also known as

A

Chigger borne disease

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20
Q

Zoonotic tetrad of Scrub typhus

A

Chiggers larvae - transported by trombiculid mites, Carry infection in Rats/Squirrel, Infect humans, Present in vegetation/Shrubs

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21
Q

Pathogenesis of Scrub typhus

A

Mite larvae/Chiggers - Seek moist areas of body (Axilla, groin) - After 1-3 weeks Eschars at site of bite along with Fever , Nausea, vomiting, Lymphadenopathy

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22
Q

Complications of Scrub typhus

A

Pneumonia, ARDS, Shock

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23
Q

Special stains used for diagnosis of Ricketssial organisms

A

Giemsa
Castaneda
Gimenez
Macchiavello

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24
Q

Culture used in Ricketssial infections

A

Yolk sac of embryonated hen’s egg
Cell lines (Vero, Hela, Hep2, Detroit 6)

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25
Q

Serological test done for diagnosis of Ricketssial infections

A

Weil Felix reaction
IgM (ELISA)

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26
Q

Weils Felix reaction findings

A

Scrub typhus - OXK +ve
Others - OX19 and OX 2 +ve
Brill zinser - not shows any positivity

27
Q

False Positive Weil Felix reaction can be seen in

A

Proteus infection

28
Q

Gold standard serological test for Ricketssial infections

A

Indirect fluorescence antibody test

29
Q

Treatment of Ricketssial infections

A

Doxycycline or Tetracycline

30
Q

Genius Coxiella is part of which family

A

Rickettsiae

31
Q

Features of Coxiella brunetti

A

Intracellular parasite
Has no vector
No weil Felix reaction
No rash

32
Q

Transmission methods of Coxiella brunetti

A

Inoculation - Vets
Inhalational - dried feces
Ingestion - Meat,Milk

33
Q

Coxiella brunetti causes

A

Q fever
Intestinal Pneumonia
Chronic hepatitis, Endocarditis

34
Q

Histopathology finding in Q fever

A

Doughnut granuloma or Fibrin ring Granuloma

35
Q

Stain used for diagnosis of Coxiella brunetti

A

Giemsa
Gimenez
Castaneda
Macchiavello

36
Q

Treatment of Coxiella brunetti infection

A

Tetracycline

37
Q

Vaccine available for Q fever

A

Q vax - In Australia - for more than 15 yrs of age

38
Q

All Ricketssiae are Obligate intracellular except

A

Bartonella

39
Q

Bartonella includes

A

Bartonella Bacilliformis
Bartonella Quintana
Bartonella Henselae

40
Q

Bartonella Bacilliformis is also known as and transmitted by

A

AKA Oroya fever and transmitted by Sand fly

41
Q

Clinical features of Bartonella Bacilliformis infection

A

Fever
Hemolytic anemia

42
Q

Bartonella Henselae causes

A

Cat scratch disease
Bacillary angiomatosis
Bacillary peliosis (Liver, spleen)

43
Q

Stellate granulomas is seen in

A

Cat scratch disease caused by Bartonella Henselae

44
Q

Stain used for diagnosis of Bartonella Henselae infection

A

Warthin and silver starry stain

45
Q

Bartonella Quintana causes

A

Five day fever/Trech fever
No animal reservoir
Only in humans

46
Q

Bartonella Quintana infection is transmitted by

A

Body louse

47
Q

Chlamydia features

A

3ABC
Atypical bacteria
Do not grown on Artificial media (Obligate intracellular)
ATP From host (ATP Parasite)
Basophilic bacterial inclusions
Cannot be Cultured
No peptidoglycan cell wall

48
Q

Types of Chlamydia

A

Chlamydia - Chlamydia trachomatis
Chlamyodophila - Chlamydophila pneumoniae, Chlamydophila psittace

49
Q

FORMS Or BODY of Chlamydia

A

Elementary body
Reticulate body

50
Q

Features of Elementary body

A

EEEII
Elementary
Extracellular
Equal - RNA = DNA
I - Metabolically inactive
I - Infectious form
Small

51
Q

Reticulate body of Chlamydia features

A

Intracellular
RNA > DNA
Metabolically active
Large
Replicating form

52
Q

Serotype A, B, Ba, C of C. Trachomatis and causes

A

A,B,Ba,C - causes Trachoma

53
Q

Serotype of C. Trachomatis and causes

A

A,B,Ba,C - causes Trachoma

54
Q

Most common infectious cause of Blindness in India is

A

Trachoma caused by Chlamydia trachomatis - M/C Type B

55
Q

D,E,F,G,H,I,K Serotypes of Chlamydia trachomatis causes

A

Non gonococcal urethritis - discharge
Opthalmia neonatarum
Inclusion conjunctivitis (not cause blindness)
Infant pneumonia

56
Q

L1,L2,L3 serotypes of Chlamydia are known to cause

A

Lymphogranuloma venereum - M/C - L2

57
Q

Clinical features of Lymphogranuloma venereum

A

ABCDEFG
A - Asymptomatic
B - Bubos (Painful LN) - Inflamed inguinal LN - Groove sign
C - C. Trachomatis L1,L2,L3
D - Doxycycline (DOC)
E - Esthionine (Rectal and vulval stricture)
F - Freisz test (skin test), Fitz hugh Curtis Syndrome (Perihepatitis)
G - Groove sign

58
Q

Strains of C. Pneumoniae and C. Psittaci

A

C. Pneumoniae - one strain (Twar)
C. Psittaci - many strains

59
Q

Stains used for Diagnosis of C. Trachomatis infection

A

Gram poor
Giemsa
Grimenez
Castenada
Macchiavello

60
Q

Cells lines methods used for diagnosis of C. Trachomatis

A

Hela
Hep2
McCoy

61
Q

Most sensitive and specific test for diagnosis of C. Trachomatis

62
Q

Chlamydia pneumoniae causes

A

Taiwan acute respiratory strain - 3rd most common cause of CAP

63
Q

Chlamydia pneumoniae is associated with

A

Atherosclerosis
Asthma
Sarcoidosis

64
Q

C. Psittaci causes and transmission

A

Causes pneumonia
Transmitted from birds(Parrots) to human

Microbiology (37 decks)

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