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Microbiology > DNA Viruses Part 2 > Flashcards

DNA Viruses Part 2 Flashcards

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Biology 101 flashcards
1
Q

Smallest virus

A

Parvoviridae - Parvovirus (20nm)

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2
Q

Parvoviridae Features

A

Smallest virus
ssDNA
Icosahedral Symmetry

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3
Q

Spread of Parvoviridae

A

Respiratory route
Blood Transfusion
Transplacental transmission

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4
Q

Parvoviridae attacks which antigen

A

Attack P antigen of RBC precursor

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5
Q

Genotypes and Serotypes of Parvoviridae

A

3 genotypes - Parvoviridae 1(M/C), 2 and 3
Serotype 1

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6
Q

Conditions associated with Parvovirus B19

A

Erythema infectiosum (5th disease,slapped chick appearance)
Gloves and socks Syndrome
Arthritis, Arthralgia
Aplastic crisis (in Hemolytic anemia)
Pure red cell aplasia (PRCA)
Hydrops fetalis

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7
Q

Erythema infectiosum Clinical features

A

AKA 5th disease/Slapped cheek appearance
Macular erythematous rash on cheek
Lacy rash on rest of body
Self limiting condition

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8
Q

Gloves and socks Syndrome also known as

A

PPGSS - Papular Perpeuric Gloves and Socks Syndrome

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9
Q

Pure red cell aplasia (PRCA) is associated with which conditions

A

Parvo B19 virus
Thymoma

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10
Q

Diagnosis of Parvoviridae

A

ELISA For Antibody
PCR for DNA

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11
Q

First disease AKA

A

Measles

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12
Q

Second disease AKA

A

Scarlet fever

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13
Q

Third disease AKA

A

German measles

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14
Q

Fourth disease AKA

A

DUKE (Obsolete)

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15
Q

Fifth disease AKA

A

Slapped cheek/Erythema infectiosum

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16
Q

Sixth disease AKA

A

Roseola infantum/HHV 6

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17
Q

Papovaviridae Family includes

A

Papilloma virus
Polyoma Virus

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18
Q

Polyoma Virus includes

A

Merkel cell virus (MCV)
SV40 (Simian Vacuolatin
JC Virus
BK Virus

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19
Q

Merkel cell virus known to cause

A

Merkel cell carcinoma - Neuroendocrine tumor
CK 7 -ve, CK 20 +ve

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20
Q

SV40 (Simian Vacuolating) is associated with

A

Non pathogenic to human
Associated with Mesothelioma

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21
Q

JC Virus attacks which cells and causes

A

Attacks oligodendrocytes
Causes demyelinating syndrome - Progressive Multifocal Leukoencephalopathy (PMLE)

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22
Q

Myelin stain used in PMLE and finding

A

Luxol fast blue - Negative in PMLE

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23
Q

BK Virus causes

A

Interstitial Nephritis
Hemorrhagic Cystitis
Usually seen in Post transplant pt.

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24
Q

Urine M/E finding in BK virus

A

Large cell - Decoy cells (High N/C ratio mimics cancer)

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25
Q

Human Papilloma virus involves which organs

A

Cutaneous involvement - HPV 1,2,3 (low risk) ; HPV 5,8 (High risk)
Mucosal involvement - HPV 6,11(low risk) ; HPV 16,18,31,33,35 (High risk)

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26
Q

HPV 1,2,3 causes

A

Low risk
Plantar wart
Filiform wart

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27
Q

HPV 5,8 known to cause

A

Epidermodysplasia Verruciforms/Tree man Syndrome - a/w With chr. 17

28
Q

HPV 6,11 Causes

A

Laryngeal Papillomatosis
Condylomata Acuminatum (Genital warts)

29
Q

L1 capsid protein of HPV is used for

A

Used for preparing vaccine

30
Q

E2 protein of HPV is used as

A

Controller

31
Q

E4 and E5 Protein of HPV known to show which structure

A

Koilocytosis - Koilocyte +ve

32
Q

E6 and E7 Protein of HPV is responsible for

A

Carcinogenesis - Squamous epithelium - Cervical cancer, Penile cancer, Anal canal cancer, Oral cancer, Laryngeal Cancer, esophageal cancer)

33
Q

E6 protein inactivates which gene

A

P53 (Policeman)

34
Q

E7 protein of HPV inactivates which gene

A

RB gene (Governer)

35
Q

Diagnosis of HPV Infection

A

Screening - Pap smear
Confirmatory - Biopsy (Koilocyte +)
Molecular tests - PCR, Hybrid capture assay

36
Q

Vaccines for HPV

A

Cervarix
Gardasil
Gardasil 9

37
Q

Cervarix vaccine adjuvant and provides protection against

A

Bivalent
Adjuvant - ASO4 (Act on TLR’s - enhances immunity)
Protection - HPV 16,18

38
Q

Gardasil vaccine provides protection against

A

Quadrivalent
Protection against HPV 6,11,16,18

39
Q

Poxviridae family includes

A

Vaccinia (Cowpox)
Variola (Smallpox)
Molluscum Contagiosum
Monkey pox

40
Q

Size, shape, symmetry, and replication site in Poxviridae family

A

Size - 300nm (Largest)
Shape - Box/brick With Dumbell DNA core
Symmetry - Complex
Replication site - Cytoplasm

41
Q

Variola/small pox incubation period

A

12 days

42
Q

Crop and fever in case of Smallpox

A

No crop
No fever with crop - fever subsides with rash

43
Q

Distribution of rash in Smallpox

A

Centrifugal (from extremities) to centripetal (Trunk)

44
Q

Vaccine used against Variola/Smallpox

A

1st vaccine - Edward Jenner(Using cowpox)
Live vaccinia vaccine - freeze dried preparation

45
Q

Cytopathic effect shown by Variola and Vaccinia

A

Vaccinia - Guarnieri body
Variola - Paschen body

46
Q

Vaccinia on Chorioallantoic Membrane shows

A

Large, hemorrhagic necrotic lesions

47
Q

Variola on Chorioallantoic Membrane shows

A

Small, non hemorrhagic lesions

48
Q

Molluscum Contagiosum is most commonly caused by

A

Molluscum contagious virus 1 (M/C) and 2

49
Q

Transmission of Molluscum contagious virus

A

In child and adults - by contact

50
Q

Characteristic Findings of Molluscum Contagiosum lesions

A

Tam color umbilicated lesions - on pressing, curdy discharge
Seen all over body except Palms, soles

51
Q

Cytopathic effect caused by Molluscum Contagiosum virus

A

Cup shaped
Henderson Patterson bodies (HP Body)

52
Q

Stained used to see Henderson Patterson bodies

A

Phloxine Tartarate stain - also used to stain Paneth cells (GIT)

53
Q

E/M finding in case of Molluscum contagious virus

A

Brick/box shape with Dumbell core

54
Q

Reservoir of Monkeypox

A

Rodents

55
Q

Mode of transmission of Monkey pox

A

Zoonotic - bites, scratches, Consumption of bush meat
Human to human transmission possible

56
Q

Incubation period and clinical features of Monkey pox

A

IP - 2 weeks
C/F - Fever,Rash, Lymphadenopathy

57
Q

Shape of Adenovirus

A

Space vehicle shape

58
Q

Fibers rising from surface of Adenovirus helps in

A

Attachment

59
Q

Clinical features caused by Adenovirus

A

Hemorrhagic Cystitis
Infant diarrhea
Involvement of Eyes
Respiratory diseases

60
Q

Which type of Adenovirus involved in case of Hemorrhagic Cystitis

A

11,21

61
Q

Type of Adenovirus responsible for Infant diarrhea

A

40,41

62
Q

Clinical features related to eyes caused by Adenovirus

A

Epidemic Keratoconjunctivitis/Shipyard eye
Pharyngoconjunctival fever/swimming pool Conjunctivitis

63
Q

Epidemic Keratoconjunctivitis/Shipyard eye caused by which adenovirus

A

AKA Epidemic follicular conjunctivitis - Corneal opacities
Type 8,19,37

64
Q

Pharyngoconjunctival fever/ swimming pool Conjunctivitis clinical features and types involved

A

H/O swimming
Pharyngitis
Follicular conjunctivitis (U/L or B/L)
In children’s

65
Q

Respiratory diseases caused by Adenovirus and types involved

A

URTI - 1,2,3,5
Pneumonia - 3,7,21
Transplant recipients - 34,35

Microbiology (37 decks)

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