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Microbiology > COVID 19 And miscallenous Viruses > Flashcards

COVID 19 And miscallenous Viruses Flashcards

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Biology 101 flashcards
1
Q

Family and genus of Coronavirus

A

Family - Coronaviridae
Genus - Beta coronavirus

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2
Q

Features of Coronavirus

A

Non segmented
Positive sense RNA
ssRNA

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3
Q

Structure present in Coronavirus

A

Spike (S1 and S2) - helps in attachment
Nucleocapsid (N)
Membrane (M)
Envelope (E)

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4
Q

Coronavirus attaches to which receptors and location

A

1) Spike proteins attaches on ACE2 Receptors
Maximally present in Lungs (type 2 pneumocytes), GIT, Heart, Kidney

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5
Q

Activation of spike protein in coronavirus happens through

A

TMPRSS2

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6
Q

Pathogenesis of COVID 19

A

Attachment - Endocytosis - Uncoating - Viral Replication - Viral assembly and Release

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7
Q

When Max shedding in COVID-19 occurs

A

Occurs 5-8 hrs before onset of symptoms

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8
Q

Clinical features of COVID-19

A

Fever
Dyspnea
Dry cough
Shortness of breath
Loss of smell and taste
GI Complaints
Myalgia

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9
Q

Radiological findings seen in COVID-19

A

Multifocal ground glass opacities
Consolidation
Pavement appearance (multiple GGO’s with septal thickening)
Reverse halo sign

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10
Q

Collection of COVID-19 sampe

A

Upper respiratory specimen - Nasopharyngeal and oropharyngeal swab
Lower resp specimen - BAL, ET Aspirate, sputum

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11
Q

Gold standard method of diagnosis of COVID-19 and turn around time

A

Real time RT PCR
Turn around time - 4-6 hrs

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12
Q

Semi confirmatory genes for COVID-19

A

F gene
N gene
S gene

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13
Q

Confirmatory genes for COVID-19

A

RdRP gene
ORF1 alpha gene

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14
Q

CBNAAT or True NAAT procedure in case of COVID 19

A

Portable PCR <30 min
2 steps - E gene screening (semi confirmatory gene) - If +ve - Check RdRP(Confirmatory) - If -ve - RRTPCR

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15
Q

Rapid card test for COVID-19 principle is based on

A

Immunochromtatography

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16
Q

FELUDA test

A

Fn Cas9 Editor linked uniform detection assay
Principle - Crispr Cas9
Paper based Test strip
Time <45 min

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17
Q

Reservoir for Arenaviridae family

A

Rodents

18
Q

Arenaviridae features

A

Negative sense RNA
Segmented RNA Virus - 2 segments
Bioterrorism A agent
Sand sprinkled /sandy appearance

19
Q

Arenaviridae family includes

A

Lassavirus
Junin virus
Machupovirus
Lymphocytic choriomeningitis virus

20
Q

Which Arenaviridae family members known to cause Hemorrhagic fever

A

Lassavirus
Junin virus
Machupovirus

21
Q

Lymphocytic choriomeningitis virus Causes

A

Meningitis

22
Q

Reoviridae family includes

A

Rotavirus

23
Q

Rotavirus release which toxin

A

NSP4 Enterotoxin

24
Q

Structural protein of Rotavirus

A

VP 1-4,6,7

25
Q

Non structural proteins for Rotavirus

A

NSP 1-6

26
Q

Serotypes of Rotavirus and most common one

A

A to I - Serogroup A is most common cause of diarrhea in children of less than 5 years

27
Q

IP and Transmission route of Rotavirus

A

Feco oral route
IP - 1 to 3 days
Small infectivity dose

28
Q

Rotavirus shape on E/M

A

Rotating wheel shape

29
Q

Vaccine of Rotavirus and side effect

A

Rotateq
Rotatrix
S/E - Intussception

30
Q

Which is the only dsRNA virus

A

Reo/Rotavirus
Segmented - 11 segments

31
Q

Filoviridae family includes

A

Ebola virus
Marburg virus

32
Q

Ebola virus shape and transmission

A

Bowl of spaghetti/Filamentous
Spread - secretions, contact

33
Q

Marburg virus is known to cause

A

Hemorrhagic fever

34
Q

Reservoir host of Ebola virus

A

Bats

35
Q

Species of Ebola virus and virulence

A

Zaire ebola - Most virulent
Ivory coast and - least virulent
Reston - not known to cause disease

36
Q

Incubation period of Ebola virus

A

3-14 days

37
Q

Treatment of Ebola virus

A

Supportive
Inmazeb - Combination of Atoltivimab, Maftivimab, Odesivimab

38
Q

Vaccine for Ebola virus infection

A

Ebola zaire vaccine

39
Q

Viruses causing gasteroenteritis

A

Adenovirus 40,41
Rotavirus
Norwalk virus (Noroviridae)
Calcivirus (Hep E)
Astrovirus

40
Q

Hemorrhagic fevers Mnemonic

A

AB Hoga FFvR
Arena virus
Bunyavirus - Crimian congo, Rift valley fever, Hantavirus
Flavivirus - Dengue, Yellow fever, KFD
Filovirus - Ebola, Marburg virus
Reovirus - Colorado tick fever

Microbiology (37 decks)

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