Reumatograma Flashcards

1
Q

FAN positivo en

A
  • AR
  • AIJ
  • ESP
  • CREST
  • Sjogren
  • EMTC
  • LES

FAN positivo siempre que hay auto-inmunidad

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2
Q

FR positivo en

A
  • AR
  • AIJ 20%
  • Sjogren
  • Policondritis Recidivante
  • Poli Arteritis Nodosa (PAN)
  • Wegener
  • Churg-Strauss
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3
Q

Laboratorio Inmunológico de LES

A

FAN (solo FAN no hace dx) < 1/80 es negativo
Anti-ADN
Anti-Sm (marcador de afeccion renal)
Anti-Ro
Anti-La
Anti-RNP
Anti-scl70

Anti-Cardiolipina
Anti-B2-glicoproteina
VDRL

Coombs Directa (AHAI)
Factores del complemento (3 y 4 disminuídos)
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4
Q

Laboratorio Serologia Sjogren

A

FR +
ANA aumentado
Anti-Ro y Anti-La presentes (más utiles, pero no específicos, Dif LES) que determinan inicio precoz, recurrente y mas grave.

Anticuerpos RO-LA (un tipo de paloma)

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5
Q

Laboratorio Especifico Esclerodermia

A
  • FAN + (ANA, AAN)
  • Ac Anti-centromero: Cutanea Limitada / CREST
  • Ac anti-topoisomerasa 1 (anti-Scl70): Sistemica difusa
  • Anti-RNA polimerasa 3: afeccion renal esclerodermica, esclero sin esclero
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6
Q

Anti-CCD positivo en

A

AR

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7
Q

ANCA-C (Ac citoplasmaticos anti-citoplasma de neutrofilos) positivo en

A

Wegener (con PR3 +)

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8
Q

ANCA-P (Ac perinucleares anti-citoplasma de neutrofilos) positivo en

A

PAN (pero con MPO y PR3 neg)

Churg-Strauss

PAM

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9
Q

Anti-proteinasa 3 (PR3) sirve para

A

Fidedignidade a ANCA-C

Positivo en:

Wegener

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10
Q

Anti-Mieloperoxidasa (MPO) sirve para

A

Fidedignidade a ANCA-P

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11
Q

Artritis Sero-Negativas

A

Espondilitis Anquilosante
Psoriasica
Reiter
Enteropaticas
Espondiloartropatia Juvenil

HLA-B27

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12
Q

OMD con luz polarizada - Morfologia de los cristales

A

Urato monosodico: forma de aguja, intra y extracelulares, birrefringencia negativa

Pirofosfato calcico: cilindricos, romboidales, birrefringencia + debil

Hidroxiapatita: aglutinados, globulares, no refringentes

Colesterol: placas rectangulares, cruces de malta, birref neg.

Oxalato de Ca: bipiramidad, birref +

Cristales de corticoides

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13
Q

Laboratorio en las enfermedades osteometabolicas (Ca++, Fosforemia y FAL)

A
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14
Q

Laboratorio Serología PM/DM

A

Anti-Jo1 (anti-sintetasa)

ANA

Mi1 (manto)

Anti-SRP

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15
Q

EMTC - Lab

A

Anti RNP U1 (especifico y sensible)

ANA moteado en altos titulos

Puede haber:

Anti-Ro

Anti-La

Anti-ADN

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16
Q

Policondritis Recidivante - Laboratorio

A
  • FR
  • ANCA
  • AC anti colágeno 2
17
Q

Lab Específico para Vasculitis

A
  • Temporal: nada
  • Takayasu: nada
  • PAN: FR +, FAN neg, ANCA-P +, MPO y PR3 negativos, HBsAg o HBeAg +
  • Kawasaki: nada
  • Wegener: FR+, ANCA-C +, PR3 +, hipergammaglobulinemia
  • Churg-Strauss: FR +, ANCA-P +, IgE, IL-5, Hipergammaglobulinemia, Eosinofilos > 1000
  • PAM: ANCA-P +
  • Scholein-Henoch: nada
  • Crioglobulinemica: nada
  • Hipocomplementemica: nada
  • Behçet: nada, puede tener FAN+
  • Cogan: nada