Pharm small group: HIV 3

Question 1

What is the DOC for PCP?

Answer 1

TMP-SMX

Question 2

What is the MOA of trimethoprim?

Answer 2

Reversibly inhibits dihydrofolate reductase

Question 3

What is the MOA of sulfamethoxazole?

Answer 3

competitively inhibits dihydropteroate synthase

Question 4

What does dihydropteroate synthase do?

Answer 4

incorporates PABA into dihydropteroic acid, the immediate precursor of folic acid

Question 5

Trimethoprim exerts a synergistic effect with what?

Answer 5

Sulfanomides

Question 6

High dose therapy with TMP-SMX can lead to what skin adverse effects?

Answer 6

1) Erythematou, maculopapular, morbilliform rash
2) severe urticaria
3) Exfoliative dermatitis
4) Steven Johnson Syndrome

Question 7

What are the hemotological side effects of TMP-SMX toxicity?

Answer 7

1) Leukopenia
2) Anemia
3) Thrombocytopenia

Question 8

What is a common AE with TMP-SMX toxicity

Answer 8

GI (N/V abdominal pain)

Question 9

What adjunctive corticosteroid therapy is given in patients with moderate-severe PCP? (p02 <70)

Answer 9

Oral Prednisone or IV Methylprednisone