15.0 Anticancer

Question 1

When are tumors first visible on X-ray?

Answer 1

10 to the 8th

Question 2

What drugs acts only on G2 phase?

Answer 2

Bleomycin (antitumor antibiotic)

Question 3

Each cycle of chemotherapy kills what percentage of cancer cells?

Answer 3

99% (2 log reductions)

Question 4

Anticancer cells kill which rapidly dividing normal cells? Effects?

Answer 4

–Bone marrow: leads to neutropenia & thrombocytopenia

–GI mucosa: leads to mucositis & blisters

–Hair follicle: leads to alopecia

–Gonads: Infertility

Question 5

Which drugs have a higher chance of causing secondary cancers?

Answer 5

procarbazine,
melphalan,
cisplatin

Question 6

What are the adverse effects of Cyclophosphamide & Ifofamide

Answer 6

Hemorrhagic cystitis

Question 7

AE of Bleomycin

Answer 7

Pulmonary fibrosis

Question 8

AE of Cisplatin

Answer 8

Nephrotoxicity & Deafness

Question 9

AE of Doxorubicin & Daunorubicin

Answer 9

Dilated cardiomyopathy

Question 10

AE of Vincristine

Answer 10

Peripheral neuropathy

Question 11

AE of Etoposide, Methotrexate & Vinblastine

Answer 11

Bonemarrow suppression

Question 12

AE of L-Asparaginase

Answer 12

Pancreatitis and bleeding

Question 13

Minimize Hemorrhagic cystitis by cyclophosphamide & ifosfamide

Answer 13

MESNA

Question 14

Minimize Hemorrhagic cystitis by cyclophosphamide & ifosfamide

Answer 14

Good hydration and amifostine

Question 15

Minimize Doxorubicin & daunorubicin induced dilated cardiomyopathy

Answer 15

Dexrazoxane

Question 16

Mnimize Bonemarrow suppression by various drugs

Answer 16

Filgrastim (GM-CSF)

Question 17

Minimize Methotrexate induced bonemarrow suppression

Answer 17

Leucovorin (Tetrahydrofolic acid)