10.2 Anti-virals

Question 1

What is Trifluridine the DOC for?

Answer 1

• Drug of choice for HSV keratoconjunctivitis and

recurrent epithelial keratitis

Question 2

What is the MOA of Penciclovir?

Answer 2

• Monophosphorylated by viral thymidine kinase

• Further phosphorylation occurs to give active triphosphate
form

• Inhibit HSV DNA polymerase / chain terminator

Question 3

Which purine & pyrimidine analog has the adverse effect of Palpebral edema?

Answer 3

Trifluridine