Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > 3 DMARDs > Flashcards

3 DMARDs Flashcards

1
Q

How long does it take for DMARDs to take clinical effects?

A

6 weeks to 6 months

Some within 2 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the first choice to treat rheumatoid arthritis?

A

Methotrexate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the MOA for methotrexate?

A

Inhibits AICAR transformylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What does AICAR transformylase do?

A

Catalyzes the penultimate and final steps in de novo purine biosynthesis which leads to synthesis of IMP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Inhibition of AICAR transformylase results in the accumulation and release of what?

A

Adenosine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How does adenosine act as a potent anti-inflammatory mediator?

A

Acts on A2b receptors and suppresses NF-kB activation induced by TNF and other inflammatory stimuli

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Besides blocking IMP, what other pathway does Methotrexate affect?

A

Thymidylate synthase pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the MOST COMMON adverse effects of Methotrexate?

A

Nausea and mucosal ulcers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How is Methotrexate toxicity reduced?

A

Leucovorin or folic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Can methotrexate be used in pregnancy?

A

No.

Contraindicated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Cyclosporine binds to what?

A

Cyclophilin (an immunophilin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Cyclosporin-Cyclophilin complex inhibits what?

A

Calcineurin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the dose limiting adverse affect of cyclosporine?

A

Nephrotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which drug is a purine antimetabolite?

A

Azathioprine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is Azathioprine converted to?

A

6-mercaptopurine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the action of 6-mercaptopurine?

A

inhibits de novo synthesis if purine synthesis

17
Q

What is azathioprine used for?

A

Refractory rheumatoid arthritis

18
Q

What is the MOA of cyclophophamide?

A

Cross links DNA, thereby preventing cell replication

19
Q

What are the gold compounds?

A
  • Gold sodium thiomalate

- Auranofin

20
Q

Gold salts are taken up by what? Resulting in?

A
  • Macrophages

- Supress phagocytosis and lysosomal enzymes

21
Q

Which are the anti-TNF drugs?

A

1) Adalimumab
2) Infliximab
3) Entanercept

22
Q

What must be done before putting a patient on a anti-TNF drug?

A

Screen for TB

before and during treatment

23
Q

Which is the anti-interleukin drug?

A

Anakinra

24
Q

What is the MOA of anakinra?

A

IL-1 receptor antagonist?

25
Q

Leflunomide in combination with methotrexate increases risk of what?

A

Hepatotoxicity

26
Q

The combination of different biological agents increases risk of what?

A

Neutropenia and infections

Pharmacology (70 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions